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LAS1L [nucleoplasm]
Stable Identifier
R-HSA-6791521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ribosomal biogenesis protein LAS1L, LAS1L_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q5S007
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)
LAS1L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4W2 LAS1L
Gene Names
LAS1L, MSTP060
Chain
chain:1-734
Reference Genes
BioGPS Gene:81887 LAS1L
COSMIC (genes):LAS1L LAS1L
CTD Gene:81887 LAS1L
dbSNP Gene:81887 LAS1L
ENSEMBL:ENSG00000001497 LAS1L
ENSEMBL_homo_sapiens_GENE:ENSG00000001497.18 LAS1L
HGNC:25726 LAS1L
KEGG Gene (Homo sapiens):81887 LAS1L
Monarch:81887 LAS1L
NCBI Gene:81887 LAS1L
OMIM:300964 LAS1L
UCSC:Q9Y4W2 LAS1L
Reference Transcript
RefSeq:NM_031206.4 LAS1L
RefSeq:NM_001170650.1 LAS1L
RefSeq:NM_001170649.1 LAS1L
Other Identifiers
11721074_a_at
11762896_a_at
17111688
208117_PM_s_at
208117_s_at
38260_at
4010861
4010862
4010863
4010868
4010874
4010875
4010876
4010883
4010884
4010885
4010886
4010887
4010888
4010890
4010892
4010893
4010895
4010897
4010898
4010899
4010900
4010904
4010905
4010906
4010907
4010908
4010909
8173269
81887
A_23_P256021
GE84548
GE86549
GO:0000460
GO:0000470
GO:0003723
GO:0003824
GO:0004519
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006364
GO:0016020
GO:0016787
GO:0030687
GO:0042254
GO:0043226
GO:0071339
GO:0090730
HMNXSV003003039
HMNXSV003051079
HMNXSV003056606
ILMN_1774890
PH_hs_0017294
TC0X001098.hg
g13654269_3p_s_at
Participates
as a component of
28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm] (Homo sapiens)
32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA
(Homo sapiens)
Inferred To
Las1l [nucleoplasm]
(Mus musculus)
Las1l [nucleoplasm]
(Rattus norvegicus)
las1 [nucleoplasm]
(Schizosaccharomyces pombe)
las1l [nucleoplasm]
(Xenopus tropicalis)
LAS1 [nucleoplasm]
(Saccharomyces cerevisiae)
CG6316 [nucleoplasm]
(Drosophila melanogaster)
LAS1L [nucleoplasm]
(Bos taurus)
LAS1L [nucleoplasm]
(Caenorhabditis elegans)
LAS1L [nucleoplasm]
(Canis familiaris)
LAS1L [nucleoplasm]
(Dictyostelium discoideum)
LAS1L [nucleoplasm]
(Gallus gallus)
LAS1L [nucleoplasm]
(Sus scrofa)
Ghost homologue of LAS1L [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_112483.1
,
NP_001164120.1
,
NP_001164121.1
OpenTargets
ENSG00000001497
HPA
ENSG00000001497-LAS1L
GeneCards
Q9Y4W2
Ensembl
ENST00000374807
,
ENSP00000473471
,
ENSP00000363940
,
ENSP00000363937
,
ENSP00000363944
,
ENST00000374811
,
ENSG00000001497
,
ENST00000484069
,
ENST00000374804
PRO
Q9Y4W2
Pharos - Targets
Q9Y4W2
Orphanet
22975
PDB
8FL4
,
8FL2
,
8FL3
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P0C6X7-PRO_0000037309 REP
0.508
2
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.462
2
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