Reactome: A Curated Pathway Database

NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841

Stable Identifier
R-HSA-6793057
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr et al. 2012, Yakubovskaya et al. 2012) and recruits NSUN4 to the ribosome where NSUN4 transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-841 in 12S rRNA (Camara et al. 2011). Knockout of MTERF4 in mice is lethal and cardiomyocyte-specific knockout is accompanied by mitochondrial cardiomyopathy (Camara et al. 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
rRNA (cytosine-C5-)-methyltransferase activity of MTERF4:NSUN4 [mitochondrial matrix] MTERF4:NSUN4 [mitochondrial matrix] rRNA (cytosine-C5-)-methyltransferase activity (0009383)