NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841

Stable Identifier
R-HSA-6793057
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841
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MTERF4 forms a complex with NSUN4 (Camara et al. 2011, Spahr et al. 2012, Yakubovskaya et al. 2012) and recruits NSUN4 to the ribosome where NSUN4 transfers a methyl group from S-adenosylmethionine to the 5 position of cytidine-841 in 12S rRNA (Camara et al. 2011). Knockout of MTERF4 in mice is lethal and cardiomyocyte-specific knockout is accompanied by mitochondrial cardiomyopathy (Camara et al. 2011).
Literature References
PubMed ID Title Journal Year
22949673 Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis

Spåhr, H, Habermann, B, Gustafsson, CM, Larsson, NG, Hallberg, BM

Proc. Natl. Acad. Sci. U.S.A. 2012
23022348 Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification

Yakubovskaya, E, Guja, KE, Mejia, E, Castano, S, Hambardjieva, E, Choi, WS, Garcia-Diaz, M

Structure 2012
21531335 MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome

Cámara, Y, Asin-Cayuela, J, Park, CB, Metodiev, MD, Shi, Y, Ruzzenente, B, Kukat, C, Habermann, B, Wibom, R, Hultenby, K, Franz, T, Erdjument-Bromage, H, Tempst, P, Hallberg, BM, Gustafsson, CM, Larsson, NG

Cell Metab. 2011
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
rRNA methylation (0031167)
Catalyst Activity

rRNA (cytosine-C5-)-methyltransferase activity of MTERF4:NSUN4 [mitochondrial matrix]

Physical Entity
MTERF4:NSUN4 [mitochondrial matrix] (Homo sapiens)
Activity
rRNA (cytosine-C5-)-methyltransferase activity (GO:0009383)
Authored
May, B  (2015-08-28)
Reviewed
Bogenhagen, DF  (2016-04-25)
Created
May, B  (2015-08-29)
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