MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370

Stable Identifier
R-HSA-6793096
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370
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MRM3 (RNMTL1) associates with the large mitochondrial ribosomal subunit and transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group of guanosine-1370 of 16S rRNA (Lee et al. 2013, Lee and Bogenhagen 2014). Inactivation of RNMTL1 causes aberrant assembly of large ribosomal subunits, decreased mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014).
Literature References
PubMed ID Title Journal Year
25074936 Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA)

Lee, KW, Bogenhagen, DF

J. Biol. Chem. 2014
24036117 Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid

Lee, KW, Okot-Kotber, C, LaComb, JF, Bogenhagen, DF

J. Biol. Chem. 2013
25009282 MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome

Rorbach, J, Boesch, P, Gammage, PA, Nicholls, TJ, Pearce, SF, Patel, D, Hauser, A, Perocchi, F, Minczuk, M

Mol. Biol. Cell 2014
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
rRNA 2'-O-methylation (0000451)
Catalyst Activity

rRNA (guanosine-2'-O-)-methyltransferase activity of RNMTL1 [mitochondrial matrix]

Physical Entity
RNMTL1 [mitochondrial matrix] (Homo sapiens)
Activity
rRNA (guanosine-2'-O-)-methyltransferase activity (GO:0070039)
Authored
May, B  (2015-08-29)
Reviewed
Bogenhagen, DF  (2016-04-25)
Created
May, B  (2015-08-29)
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