MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370

Stable Identifier
R-HSA-6793096
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

MRM3 (RNMTL1) associates with the large mitochondrial ribosomal subunit and transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group of guanosine-1370 of 16S rRNA (Lee et al. 2013, Lee and Bogenhagen 2014). Inactivation of RNMTL1 causes aberrant assembly of large ribosomal subunits, decreased mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014).

Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
rRNA (guanosine-2'-O-)-methyltransferase activity of RNMTL1 [mitochondrial matrix]
Physical Entity
Activity