Reactome: A Curated Pathway Database

MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370

Stable Identifier
R-HSA-6793096
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MRM3 (RNMTL1) associates with the large mitochondrial ribosomal subunit and transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl group of guanosine-1370 of 16S rRNA (Lee et al. 2013, Lee and Bogenhagen 2014). Inactivation of RNMTL1 causes aberrant assembly of large ribosomal subunits, decreased mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
rRNA (guanosine-2'-O-)-methyltransferase activity of RNMTL1 [mitochondrial matrix] RNMTL1 [mitochondrial matrix] rRNA (guanosine-2'-O-)-methyltransferase activity (0070039)