Reactome: A Curated Pathway Database

MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine

Stable Identifier
R-HSA-6793127
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MRM2 (FTSJ2) located in foci near mitochondrial nucleoids (Lee et al. 2013) transfers a methyl group from S-adenosylmethionine to the 2' hydroxyl of uridine-1369 in 16S rRNA (Lee and Bogenhagen 2014, Rorbach et al. 2014). Inactivation of FTSJ2 causes aberrant assembly of large mitochondrial subunits, reduced mitochondrial translation, and respiratory incompetence (Rorbach et al. 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
rRNA (uridine-2'-O-)-methyltransferase activity of FTSJ2 [mitochondrial matrix] FTSJ2 [mitochondrial matrix] rRNA (uridine-2'-O-)-methyltransferase activity (0008650)