LIPT2 transfers octanoyl group to GCSH

Stable Identifier
R-HSA-6793590
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Lipoate is an essential cofactor for five redox reactions; four in oxoacid dehydrogenases (active in energy metabolism and amino acid metabolism) and one in the glycine cleavage system (GCS). Lipoate synthesis in mitochondria requires three steps. In the first step, mitochondrial lipoyltransferase 2 (LIPT2) transfers an octanoyl group bound to an acyl-carrier protein (most likely NDUFAB1, acyl-carrier protein, ACP) to mitochondrial glycine cleavage system H protein (GCSH) at lysine 107. The human protein is thought to function in the same way as yeast LIP2 (Schonauer et al. 2009).

Literature References
PubMed ID Title Journal Year
19570983 Lipoic acid synthesis and attachment in yeast mitochondria

Schonauer, MS, Kastaniotis, AJ, Kursu, VA, Hiltunen, JK, Dieckmann, CL

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lipoyl(octanoyl) transferase activity of LIPT2 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!