Reactome: A Curated Pathway Database

(CDK1,CDK2):CCNA phosphorylates MDM2 at T218

Stable Identifier
R-HSA-6793661
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates MDM2 at threonine residue T218. Phosphorylation of MDM2 at T218 increases its affinity for p14-ARF and reduces its affinity for TP53 (p53), thus resulting in TP53 upregulation (Zhang and Prives 2001).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm] CCNA:p-CDK1/2 [nucleoplasm] cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events