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(CDK1,CDK2):CCNA phosphorylates MDM2 at T218

Stable Identifier
R-HSA-6793661
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates MDM2 at threonine residue T218. Phosphorylation of MDM2 at T218 increases its affinity for p14-ARF and reduces its affinity for TP53 (p53), thus resulting in TP53 upregulation (Zhang and Prives 2001).

Literature References
PubMed ID Title Journal Year
11359766 Cyclin a-CDK phosphorylation regulates MDM2 protein interactions J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNA:p-CDK1/2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events