MDM2 translocates to the nucleus

Stable Identifier
R-HSA-6793666
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

AKT- or SGK1-phosphorylated MDM2 residues S166 and S188 are in the vicinity of the MDM2 nuclear localization signal. MDM2 phosphorylation by AKT or SGK1 leads to MDM2 translocation from the cytosol to the nucleus (Mayo and Donner 2001).

Literature References
PubMed ID Title Journal Year
11504915 A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Participant Of
Orthologous Events