Ubiquitinated TP53 translocates to the cytosol

Stable Identifier
R-HSA-6793685
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon MDM2-mediated ubiquitination, TP53 is exported from the nucleus to the cytosol. TP53 nuclear export requires the nuclear export sequence (NES) of TP53, but not the NES of MDM2 (Boyd et al. 2000. Geyer et al. 2000).

Literature References
Participants
Participant Of
Orthologous Events