Ubiquitinated TP53 translocates to the cytosol

Stable Identifier
R-HSA-6793685
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon MDM2-mediated ubiquitination, TP53 is exported from the nucleus to the cytosol. TP53 nuclear export requires the nuclear export sequence (NES) of TP53, but not the NES of MDM2 (Boyd et al. 2000. Geyer et al. 2000).

Literature References
PubMed ID Title Journal Year
10980696 The MDM2 RING-finger domain is required to promote p53 nuclear export

Geyer, RK, Yu, ZK, Maki, CG

Nat. Cell Biol. 2000
10980695 An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

Boyd, SD, Tsai, KY, Jacks, T

Nat. Cell Biol. 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed