Reactome | STX1A [plasma membrane]

STX1A [plasma membrane]

Stable Identifier

R-HSA-6794231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Syntaxin-1A, STX1A_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - NRXNs binds MUNC18 (Homo sapiens)
      - NRXNs:STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18 [plasma membrane] (Homo sapiens)
        
        STX1A [plasma membrane] (Homo sapiens)
      - STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18 [plasma membrane] (Homo sapiens)
        
        STX1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16623 STX1A

Gene Names

STX1A, STX1

Chain

chain:1-288

Reference Genes

BioGPS Gene:6804 STX1A

COSMIC (genes):STX1A STX1A

CTD Gene:6804 STX1A

dbSNP Gene:6804 STX1A

ENSEMBL:ENSG00000106089 STX1A

HGNC:11433 STX1A

KEGG Gene (Homo sapiens):6804 STX1A

Monarch:6804 STX1A

NCBI Gene:6804 STX1A

OMIM:186590 STX1A

UCSC:Q16623 STX1A

Reference Transcript

Other Identifiers

0004570519

11720340_a_at

11748580_a_at

11751593_a_at

17058557

204729_s_at

3056227

3056228

3056230

3056231

3056235

3056237

3056238

3056239

3056242

3056244

3056248

3056249

3056256

3056257

37184_at

6804

69176

8140113

8372

A0A0C4DFZ1

A8MZ54

A_23_P168556

A_23_P82420

A_24_P226541

A_33_P3212456

AAA20940

AAA53519

AAB65500

AAH03011

AAH64644

AAK54507

AAS07469

AAS07470

AB086954

AC073846

AF297001

AF297002

AF297003

AHW56592

AK313980

BAA07151

BAC78519

BAG36694

BC000444

BC003011

BC064644

CAB008372

CAG33299

CCDS34655

CCDS55120

CH471200

CR457018

D37932

EAW69650

EAW69653

EAW69654

ENSG00000106089

ENSP00000222812

ENSP00000378585

ENST00000222812

ENST00000222812.7

ENST00000395156

ENST00000395156.7

EntrezGene:6804

EntrezGene:STX1A

g4759181_3p_a_at

GE57747

GO:0000149

GO:0001956

GO:0003674

GO:0005484

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006836

GO:0006886

GO:0006887

GO:0006906

GO:0007165

GO:0007267

GO:0007269

GO:0008021

GO:0008076

GO:0008092

GO:0008150

GO:0009629

GO:0010701

GO:0010807

GO:0012505

GO:0014047

GO:0014069

GO:0016020

GO:0016021

GO:0016079

GO:0016081

GO:0016192

GO:0016925

GO:0017022

GO:0017156

GO:0017157

GO:0019221

GO:0019855

GO:0019869

GO:0019899

GO:0019900

GO:0019904

GO:0022607

GO:0030054

GO:0030073

GO:0030141

GO:0030285

GO:0030424

GO:0030672

GO:0030674

GO:0031201

GO:0031410

GO:0031629

GO:0031965

GO:0032028

GO:0032940

GO:0032991

GO:0033605

GO:0035493

GO:0042641

GO:0042734

GO:0042802

GO:0043005

GO:0043008

GO:0043226

GO:0043229

GO:0044325

GO:0045055

GO:0045202

GO:0045921

GO:0045956

GO:0046879

GO:0046982

GO:0047485

GO:0048278

GO:0048306

GO:0048488

GO:0048787

GO:0050796

GO:0050877

GO:0061024

GO:0065003

GO:0070032

GO:0070033

GO:0070044

GO:0072657

GO:0098815

GO:0098978

GO:0099056

GO:2000463

HGNC:11433

HPA069176

ILMN_1760160

ILMN_1791371

IPR000727

IPR006011

IPR006012

IPR010989

IPR028669

KJ534952

L37792

L37792_at

MIM:186590

NM_001165903

NM_004603

NP_001159375

NP_004594

PF00804

PF05739

PH_hs_0004360

Q75ME0

SM00397

SM00503

STX1A

STX1A-201

STX1A-204

TC07001504.hg

U12918

U87310

U87314

U87315

UPI000002B444

UPI0000136065

XR_242263

XR_927527

Participant Of

hasComponent

STX1A:MUNC18 [plasma membrane]

Other forms of this molecule

STX1A [plasma membrane]

STX1A(?-288) [plasma membrane]

STX1A(1-?) [cytosol]

STX1A [cytosol]

STX1A [endoplasmic reticulum membrane]

Cross References

RefSeq

NP_004594.1, NP_001159375.1

OpenTargets

ENSG00000106089

GeneCards

Q16623

PRO

Q16623

Orphanet

22536

Interactors (120)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95721 SNAP29	3	SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997) SNAP29 [azurophil granule membrane] (R-HSA-6799359)	0.712	4
UniProt:G2XKQ0 SUMO5			0.621	3
UniProt:P63027 VAMP2	23	VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372517) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-265198) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-375436) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129)	0.621	4
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.621	3
UniProt:Q16623 STX1A	6	STX1A [plasma membrane] (R-HSA-6794231) STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.621	4
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.621	5
UniProt:O00161 SNAP23	5	p-S95-SNAP23 [phagocytic vesicle membrane] (R-HSA-8863923) SNAP23 [phagocytic vesicle membrane] (R-HSA-8863966) SNAP23 [tertiary granule membrane] (R-HSA-6806141) SNAP23 [plasma membrane] (R-HSA-376345) SNAP23 [specific granule membrane] (R-HSA-6806157)	0.553	2
UniProt:P60880-2 SNAP25			0.499	5
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.499	2
UniProt:Q13021 MALL			0.488	2
UniProt:Q92520 FAM3C	2	FAM3C [platelet dense granule lumen] (R-HSA-8848884) FAM3C [extracellular region] (R-HSA-8848922)	0.488	2
UniProt:O95183 VAMP5			0.488	2
UniProt:Q9H2L4 TMM60			0.488	2
UniProt:P52737 ZNF136	1	ZNF136 [nucleoplasm] (R-HSA-975020)	0.488	2
UniProt:Q92482 AQP3	1	AQP3 [plasma membrane] (R-HSA-431723)	0.488	2
UniProt:Q8WVX3-2 C4ORF3			0.488	2
UniProt:Q8IYI8 ZNF440	1	ZNF440 [nucleoplasm] (R-HSA-1247548)	0.488	2
UniProt:B2RUZ4 SMIM1			0.488	2
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.488	4
UniProt:Q15836 VAMP3	6	VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.488	2
UniProt:Q96C28 ZNF707	1	ZNF707 [nucleoplasm] (R-HSA-2454161)	0.488	2
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.488	2
UniProt:Q86Y82 STX12			0.488	2
UniProt:Q9BZL3 SMIM3			0.488	2
UniProt:Q8N8Z8 ZNF441	1	ZNF441 [nucleoplasm] (R-HSA-1247518)	0.488	2
UniProt:Q5SQN1 SNP47			0.488	2
UniProt:Q96HV5 TM41A			0.488	2
UniProt:Q96F15 GIMA5			0.488	2
UniProt:P26678 PLN	2	PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319) p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813)	0.488	2
UniProt:P21145 MAL			0.488	2
UniProt:Q8N5M9 JAGN1			0.488	2
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.488	2
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.488	2
UniProt:Q9NVV5-2 AIG1			0.488	2
UniProt:Q96FZ5 CKLF7			0.488	2
UniProt:A8K8V0 ZNF785	1	ZNF785 [nucleoplasm] (R-HSA-3323098)	0.488	2
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.488	2
UniProt:Q8IXM6 NRM			0.488	2
UniProt:O75558 STX11			0.488	2
UniProt:Q4LEZ3 AARD			0.488	2
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.488	2
UniProt:Q7KZS0 Q7KZS0			0.488	2
UniProt:O43752 STX6	2	STX6 [Golgi membrane] (R-HSA-6811004) STX6 [trans-Golgi network membrane] (R-HSA-6811007)	0.488	2
UniProt:O15400 STX7			0.488	2
UniProt:Q6P4E1 CASC4			0.488	2
UniProt:A0AVG3 A0AVG3			0.488	2
UniProt:Q9P2A4 ABI3			0.488	2
UniProt:Q8N511 TM199			0.488	2
UniProt:Q8N8B7-2 TCEANC			0.488	2
UniProt:P09601 HMOX1	2	HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.488	2
UniProt:Q9NVF9 ETNK2	1	ETNK2 [cytosol] (R-HSA-1498759)	0.488	2
UniProt:Q6RW13-2 AGTRAP			0.488	2
UniProt:Q5VZY2 PLPP4	1	PPAPDC1A [plasma membrane] (R-HSA-2029082)	0.488	2
UniProt:P30301 MIP	1	MIP [plasma membrane] (R-HSA-432026)	0.488	2
UniProt:O75841 UPK1B			0.488	2
UniProt:Q3SY00 T10IP			0.488	2
UniProt:O95159 ZFPL1			0.488	2
UniProt:Q9UNK0 STX8			0.488	2
UniProt:P15622-3 ZNF250			0.488	2
UniProt:Q5BJH2-2 TMEM128			0.488	2
UniProt:P0DN84 DWORF			0.488	2
UniProt:Q9Y2P0 ZN835			0.488	2
UniProt:Q9Y6X1 SERP1	2	SERP1 [cytosol] (R-HSA-5250574) SERP1 [endoplasmic reticulum membrane] (R-HSA-381045)	0.488	2
UniProt:Q6UX34 SNORC			0.488	2
UniProt:Q86W74-2 ANKRD46			0.488	2
UniProt:Q9NZG7 NINJ2			0.488	2
IntAct:EBI-12058603 CXCL16			0.488	2
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.488	2
UniProt:P23763-3 VAMP1			0.488	2
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.488	2
UniProt:P17014 ZNF12	1	ZNF12(1-501) [nucleoplasm] (R-HSA-974989)	0.488	2
UniProt:O60499-2 STX10			0.488	2
UniProt:Q9NWW5 CLN6			0.488	2
UniProt:O75379 VAMP4	4	VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.488	2
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.488	2
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [Golgi membrane] (R-HSA-6807755) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800)	0.488	4
UniProt:P54315 PNLIPRP1	1	PNLIPRP1 [extracellular region] (R-HSA-3902876)	0.488	2
UniProt:Q8N6R1 SERP2			0.488	2
UniProt:P0CB47 UBFL1			0.488	2
UniProt:Q13491-3 GPM6B			0.488	2
UniProt:Q8WWP7 GIMA1			0.488	2
UniProt:Q9UKR5 ERG28			0.488	2
UniProt:Q9UHJ9-5 PGAP2			0.488	2
UniProt:Q5QGT7 RTP2	1	RTP2 [plasma membrane] (R-HSA-8939446)	0.488	2
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [cytosol] (R-HSA-9613991)	0.488	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.488	2
UniProt:Q3SXY8 ARL13B	2	ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129)	0.488	2
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.488	2
UniProt:Q96LZ7 RMD2			0.488	2
UniProt:Q9Y6V7 DDX49	1	DDX49 [nucleoplasm] (R-HSA-6790725)	0.488	2
UniProt:Q16617 NKG7			0.488	2
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.488	2
UniProt:Q9ULM2 ZNF490	1	ZNF490 [nucleoplasm] (R-HSA-1247870)	0.488	2
UniProt:Q16853 AOC3	1	AOC3 [plasma membrane] (R-HSA-5696151)	0.488	2
UniProt:Q9H0R3 TM222			0.488	2
UniProt:Q9H7X3 ZNF696	1	ZNF696 [nucleoplasm] (R-HSA-2454138)	0.488	2
UniProt:Q9NV29 TM100			0.488	2
UniProt:O95236-2 APOL3			0.488	2
UniProt:Q8NC01 CLC1A			0.488	2
UniProt:P60201-2 PLP1			0.488	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [platelet alpha granule lumen] (R-HSA-8862964) VTI1B [extracellular region] (R-HSA-8862983)	0.488	2
UniProt:Q8TBM7 TM254			0.488	2
IntAct:EBI-17197065 C1GALT1			0.488	2
UniProt:Q8TBN0 RAB3IL1	1	RAB3IL1 [cytosol] (R-HSA-8875296)	0.488	2
UniProt:Q9Y228 T3JAM			0.488	2
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.488	2
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.488	2
UniProt:P32856-2 STX2			0.488	2
UniProt:Q9BXJ8 T120A			0.488	2
UniProt:Q8IW00 VSTM4			0.488	2
UniProt:Q96JC4 ZNF479	1	ZNF479 [nucleoplasm] (R-HSA-1247855)	0.488	2
UniProt:Q8N988-2 ZNF557			0.488	2
UniProt:Q9BQE5 APOL2			0.488	2
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.488	2
UniProt:Q9BVG8-5 KIFC3			0.488	2
UniProt:O43169 CYB5B	1	CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.488	2
UniProt:O15155 BET1	3	BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743) BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142)	0.488	2
UniProt:Q9P0S9 TM14C			0.488	2
UniProt:O14662-5 STX16			0.488	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.488	2