Reactome | STX1A [plasma membrane]

STX1A [plasma membrane]

Stable Identifier

R-HSA-6794231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Syntaxin-1A, STX1A_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - NRXNs binds MUNC18 (Homo sapiens)
      - NRXNs:STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18 [plasma membrane] (Homo sapiens)
        
        STX1A [plasma membrane] (Homo sapiens)
      - STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18 [plasma membrane] (Homo sapiens)
        
        STX1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16623 STX1A

Gene Names

STX1A, STX1

Chain

chain:1-288

Reference Genes

BioGPS Gene:6804 STX1A

COSMIC (genes):STX1A STX1A

CTD Gene:6804 STX1A

dbSNP Gene:6804 STX1A

ENSEMBL:ENSG00000106089 STX1A

HGNC:11433 STX1A

KEGG Gene (Homo sapiens):6804 STX1A

Monarch:6804 STX1A

NCBI Gene:6804 STX1A

OMIM:186590 STX1A

UCSC:Q16623 STX1A

Reference Transcript

Other Identifiers

0004570519

11720340_a_at

11748580_a_at

11751593_a_at

17058557

204729_s_at

3056227

3056228

3056230

3056231

3056235

3056237

3056238

3056239

3056242

3056244

3056248

3056249

3056256

3056257

37184_at

6804

8140113

A_23_P168556

A_23_P82420

A_24_P226541

A_33_P3212456

GE57747

GO:0000149

GO:0001956

GO:0003674

GO:0005484

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006836

GO:0006886

GO:0006887

GO:0006906

GO:0007165

GO:0007267

GO:0007269

GO:0008021

GO:0008076

GO:0008092

GO:0008150

GO:0009629

GO:0010701

GO:0010807

GO:0012505

GO:0014047

GO:0014069

GO:0015031

GO:0016020

GO:0016021

GO:0016079

GO:0016081

GO:0016192

GO:0016925

GO:0017022

GO:0017156

GO:0017157

GO:0019221

GO:0019855

GO:0019869

GO:0019899

GO:0019900

GO:0019904

GO:0022607

GO:0030054

GO:0030073

GO:0030141

GO:0030285

GO:0030424

GO:0030672

GO:0030674

GO:0031201

GO:0031410

GO:0031629

GO:0031965

GO:0032028

GO:0032940

GO:0032991

GO:0033605

GO:0035493

GO:0042641

GO:0042734

GO:0042802

GO:0043005

GO:0043008

GO:0043226

GO:0043229

GO:0044325

GO:0044877

GO:0045055

GO:0045202

GO:0045921

GO:0045956

GO:0046879

GO:0047485

GO:0048278

GO:0048306

GO:0048488

GO:0048787

GO:0050796

GO:0050877

GO:0061024

GO:0065003

GO:0070032

GO:0070033

GO:0070044

GO:0072657

GO:0098815

GO:0098978

GO:0099056

GO:2000463

ILMN_1760160

ILMN_1791371

L37792_at

PH_hs_0004360

TC07001504.hg

g4759181_3p_a_at

Participant Of

hasComponent

STX1A:MUNC18 [plasma membrane]

Other forms of this molecule

STX1A [plasma membrane]

STX1A(?-288) [plasma membrane]

STX1A(1-?) [cytosol]

STX1A [cytosol]

STX1A [endoplasmic reticulum membrane]

Cross References

RefSeq

NP_001159375.1, NP_004594.1

OpenTargets

ENSG00000106089

HPA

ENSG00000106089-STX1A

GeneCards

Q16623

Ensembl

ENST00000395156, ENSG00000106089, ENSP00000378585, ENST00000222812, ENSP00000222812

PRO

Q16623

Orphanet

22536

Interactors (119)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.666	4
UniProt:Q16623 STX1A	6	STX1A [plasma membrane] (R-HSA-6794231) STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.666	5
UniProt:P63027 VAMP2	23	VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372517) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-265198) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-375436) VAMP2 [secretory granule membrane] (R-HSA-376363)	0.666	5
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.666	4
UniProt:P21145 MAL			0.601	4
UniProt:Q16617 NKG7			0.601	4
UniProt:P09601 HMOX1	2	HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.601	4
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.601	4
UniProt:Q13021 MALL			0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:Q92520 FAM3C	2	FAM3C [platelet dense granule lumen] (R-HSA-8848884) FAM3C [extracellular region] (R-HSA-8848922)	0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:P52737 ZNF136	1	ZNF136 [nucleoplasm] (R-HSA-975020)	0.556	3
UniProt:Q8WVX3-2 C4ORF3			0.556	3
UniProt:Q92482 AQP3	1	AQP3 [plasma membrane] (R-HSA-431723)	0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:Q8IYI8 ZNF440	1	ZNF440 [nucleoplasm] (R-HSA-1247548)	0.556	3
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:Q96C28 ZNF707	1	ZNF707 [nucleoplasm] (R-HSA-2454161)	0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111)	0.556	3
UniProt:Q9BZL3 SMIM3			0.556	3
UniProt:Q86Y82 STX12			0.556	3
UniProt:Q8N8Z8 ZNF441	1	ZNF441 [nucleoplasm] (R-HSA-1247518)	0.556	3
UniProt:Q5SQN1 SNP47			0.556	3
UniProt:Q96HV5 TM41A			0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:P26678 PLN	2	PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319) p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:P78317 RNF4	2	RNF4 [cytosol] (R-HSA-975974) RNF4 [nucleoplasm] (R-HSA-5684076)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q9NVV5-2 AIG1			0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:A8K8V0 ZNF785	1	ZNF785 [nucleoplasm] (R-HSA-3323098)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:Q8IXM6 NRM			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:Q4LEZ3 AARD			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:O43752 STX6	2	STX6 [Golgi membrane] (R-HSA-6811004) STX6 [trans-Golgi network membrane] (R-HSA-6811007)	0.556	3
UniProt:O15400 STX7			0.556	3
UniProt:A0AVG3 A0AVG3			0.556	3
UniProt:Q9P2A4 ABI3			0.556	3
UniProt:Q8N511 TM199			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q9NVF9 ETNK2	1	ETNK2 [cytosol] (R-HSA-1498759)	0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q5VZY2 PLPP4	1	PPAPDC1A [plasma membrane] (R-HSA-2029082)	0.556	3
UniProt:P30301 MIP	1	MIP [plasma membrane] (R-HSA-432026)	0.556	3
UniProt:O75841 UPK1B			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:Q9UNK0 STX8			0.556	3
UniProt:Q5BJH2-2 TMEM128			0.556	3
UniProt:P15622-3 ZNF250			0.556	3
UniProt:P0DN84 DWORF			0.556	3
UniProt:Q9Y2P0 ZN835			0.556	3
UniProt:Q6UX34 SNORC			0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
IntAct:EBI-22331701 CCSB ORF ID			0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
IntAct:EBI-23653849 CCSB ORF ID			0.556	3
UniProt:P23763-3 VAMP1			0.556	3
UniProt:P17014 ZNF12	1	ZNF12(1-501) [nucleoplasm] (R-HSA-974989)	0.556	3
UniProt:O60499-2 STX10			0.556	3
UniProt:Q9NWW5 CLN6			0.556	3
UniProt:P54315 PNLIPRP1	1	PNLIPRP1 [extracellular region] (R-HSA-3902876)	0.556	3
UniProt:Q8N6R1 SERP2			0.556	3
UniProt:P0CB47 UBFL1			0.556	3
UniProt:Q13491-3 GPM6B			0.556	3
UniProt:Q8WWP7 GIMA1			0.556	3
UniProt:Q9UKR5 ERG28			0.556	3
UniProt:Q5QGT7 RTP2	1	RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q9UHJ9-5 PGAP2			0.556	3
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [cytosol] (R-HSA-9613991)	0.556	3
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.556	3
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.556	3
UniProt:Q96LZ7 RMD2			0.556	3
UniProt:Q9Y6V7 DDX49	1	DDX49 [nucleoplasm] (R-HSA-6790725)	0.556	3
UniProt:Q9ULM2 ZNF490	1	ZNF490 [nucleoplasm] (R-HSA-1247870)	0.556	3
UniProt:Q16853 AOC3	1	AOC3 [plasma membrane] (R-HSA-5696151)	0.556	3
UniProt:Q9H7X3 ZNF696	1	ZNF696 [nucleoplasm] (R-HSA-2454138)	0.556	3
UniProt:Q9H0R3 TM222			0.556	3
UniProt:Q9NV29 TM100			0.556	3
UniProt:O95236-2 APOL3			0.556	3
UniProt:Q8NC01 CLC1A			0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:Q9UEU0 VTI1B	2	VTI1B [platelet alpha granule lumen] (R-HSA-8862964) VTI1B [extracellular region] (R-HSA-8862983)	0.556	3
UniProt:Q8TBM7 TM254			0.556	3
UniProt:Q8TBN0 RAB3IL1	1	RAB3IL1 [cytosol] (R-HSA-8875296)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.556	3
IntAct:EBI-22311366 CCSB ORF ID			0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q9BXJ8 TACAN			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:O14662-5 STX16			0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:O15155 BET1	3	BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743) BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142)	0.556	3
UniProt:O43169 CYB5B	1	CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q9BQE5 APOL2			0.556	3
UniProt:Q8N988-2 ZNF557			0.556	3
UniProt:Q96JC4 ZNF479	1	ZNF479 [nucleoplasm] (R-HSA-1247855)	0.556	3
UniProt:Q8IW00 VSTM4			0.556	3
UniProt:Q3SXY8 ARL13B	7	PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986)	0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.556	3
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.556	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [Golgi membrane] (R-HSA-6807755) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800)	0.556	6
UniProt:Q9Y6X1 SERP1	2	SERP1 [cytosol] (R-HSA-5250574) SERP1 [endoplasmic reticulum membrane] (R-HSA-381045)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.556	3
UniProt:O00161 SNAP23	5	SNAP23 [phagocytic vesicle membrane] (R-HSA-8863966) p-S95-SNAP23 [phagocytic vesicle membrane] (R-HSA-8863923) SNAP23 [tertiary granule membrane] (R-HSA-6806141) SNAP23 [plasma membrane] (R-HSA-376345) SNAP23 [specific granule membrane] (R-HSA-6806157)	0.553	2
UniProt:O95721 SNAP29	3	SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997) SNAP29 [azurophil granule membrane] (R-HSA-6799359)	0.553	2
UniProt:P60880-2 SNAP25			0.499	5
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.499	2

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