Reactome | APBA2 [cytosol]

APBA2 [cytosol]

Stable Identifier

R-HSA-6794245

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Amyloid beta A4 precursor protein-binding family A member 2, APBA2_HUMAN, MINT2

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - NRXNs binds MUNC18 (Homo sapiens)
      - NRXNs:STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        MINT1,2,(3) [cytosol] (Homo sapiens)
        
        APBA2 [cytosol] (Homo sapiens)
      - STX1A:MUNC18:MINT1,2,(3) [plasma membrane] (Homo sapiens)
        
        MINT1,2,(3) [cytosol] (Homo sapiens)
        
        APBA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99767 APBA2

Gene Names

APBA2, MINT2, X11L

Chain

chain:1-749

Reference Genes

BioGPS Gene:321 APBA2

COSMIC (genes):APBA2 APBA2

CTD Gene:321 APBA2

dbSNP Gene:321 APBA2

ENSEMBL:ENSG00000034053 APBA2

HGNC:579 APBA2

KEGG:hsa:321 APBA2

Monarch:321 APBA2

NCBI Gene:321 APBA2

OMIM:602712 APBA2

UCSC:Q99767 APBA2

Reference Transcript

Other Identifiers

11727629_at

11727630_s_at

11727631_s_at

16798624

209870_PM_s_at

209870_s_at

209871_PM_s_at

209871_s_at

2797167

321

3585907

3585908

3585909

3585918

3585923

3585929

3585935

3585939

3585940

3585941

3585942

3585948

3585949

3585950

3585951

3585958

3585961

3585962

3585966

3585967

3585968

3585969

3585970

3585972

3585974

3585978

3585979

3585980

3585981

3585983

3585984

3585985

39590_at

7982187

A_14_P121452

A_23_P146849

A_23_P158231

A_33_P3344504

GE54404

GO:0001540

GO:0001701

GO:0005515

GO:0005737

GO:0005886

GO:0007268

GO:0007399

GO:0007626

GO:0010468

GO:0015031

GO:0023052

GO:0035264

GO:0042802

GO:0043197

GO:0048856

GO:0098685

GO:0098793

GO:0099171

HMNXSV003009926

HMNXSV003039880

Hs.26468.0.A1_3p_a_at

ILMN_1723626

PH_hs_0002333

TC15000153.hg

U79255_at

g3953612_3p_a_at

Participates

as a candidate of

MINT1,2,(3) [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000034053

ENSEMBL

ENST00000612449, ENSP00000480384, ENSP00000483174, ENSP00000454171, ENST00000683413, ENSP00000488107, ENST00000620457, ENST00000558330, ENST00000558402, ENSP00000409312, ENST00000558259, ENSP00000452722, ENSP00000507394, ENST00000411764, ENSP00000453293, ENST00000561069, ENST00000631894, ENSP00000453144

HPA

ENSG00000034053-APBA2

PRO

Q99767

Pharos - Targets

Q99767

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.592	2
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.527	2
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	2

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