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SHANK1 [cytosol]
Stable Identifier
R-HSA-6794274
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH3 and multiple ankyrin repeat domains protein 1, SHAN1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
ABP1 binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
HOMER binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
SHANK proteins bind GKAPs (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
SHARPIN binds SHANK proteins (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
SHARPIN:SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y566 SHANK1
Gene Names
SHANK1
Chain
chain:1-2161
Reference Genes
BioGPS Gene:50944 SHANK1
COSMIC (genes):SHANK1 SHANK1
CTD Gene:50944 SHANK1
dbSNP Gene:50944 SHANK1
ENSEMBL:ENSG00000161681 SHANK1
HGNC:15474 SHANK1
KEGG:hsa:50944 SHANK1
Monarch:50944 SHANK1
NCBI Gene:50944 SHANK1
OMIM:604999 SHANK1
UCSC:Q9Y566 SHANK1
Reference Transcript
RefSeq:XM_011527014.2 SHANK1
RefSeq:NM_016148.3 SHANK1
RefSeq:XM_006723233.3 SHANK1
Other Identifiers
11738107_a_at
16874604
214781_PM_at
214781_at
220563_PM_s_at
220563_s_at
3868582
3868583
3868585
3868586
3868588
3868589
3868590
3868591
3868593
3868595
3868596
3868597
3868598
3868599
3868600
3868601
3868602
3868603
3868604
3868605
3868609
3868610
3868611
3868613
3868614
3868615
3868616
3868617
3868621
3868622
3868623
3868625
3868626
3868627
3868628
3868630
3868631
3868632
3868633
3868634
3868635
3868636
3868638
3868639
50944
8038598
89810_at
A_23_P208636
GE56862
GE83980
GE843136
GO:0001664
GO:0005198
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007399
GO:0007616
GO:0008306
GO:0014069
GO:0016020
GO:0017124
GO:0030154
GO:0030159
GO:0030160
GO:0030425
GO:0030534
GO:0031877
GO:0032232
GO:0034330
GO:0035176
GO:0035255
GO:0035418
GO:0042048
GO:0042802
GO:0043005
GO:0043197
GO:0043226
GO:0044877
GO:0045202
GO:0045211
GO:0046959
GO:0048856
GO:0050804
GO:0050877
GO:0050885
GO:0050894
GO:0060013
GO:0060074
GO:0060076
GO:0060090
GO:0060997
GO:0060999
GO:0065003
GO:0071532
GO:0071625
GO:0097110
GO:0098685
GO:0098919
GO:0098978
GO:0099562
GO:2000311
GO:2000463
HMNXSV003000716
HMNXSV003022208
Hs.322844.1.S1_3p_at
ILMN_1747754
PH_hs_0032418
PH_hs_0039866
TC19001752.hg
TC19002552.hg
g11968151_3p_a_at
p26739
Participates
as a member of
SHANK1,2,3 [cytosol] (Homo sapiens)
Inferred To
Prosap [cytosol]
(Drosophila melanogaster)
shn-1 [cytosol]
(Caenorhabditis elegans)
Shank1 [cytosol]
(Mus musculus)
Shank1 [cytosol]
(Rattus norvegicus)
SHANK1 [cytosol]
(Bos taurus)
SHANK1 [cytosol]
(Canis familiaris)
SHANK1 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000351984
,
ENST00000359082
,
ENSP00000293441
,
ENST00000293441
OpenTargets
ENSG00000161681
HPA
ENSG00000161681-SHANK1
PRO
Q9Y566
Pharos - Targets
Q9Y566
GlyGen
Q9Y566
PDB
7A00
,
6YWZ
,
6CPI
,
6YX1
,
6YX2
,
6YX0
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYF1 ACE2
5
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
0.609
2
UniProt:Q96NW7 LRRC7
3
LRRC7 [extracellular region]
(R-HSA-6799681)
LRRC7 [specific granule lumen]
(R-HSA-6799616)
LRRC7 [cytosol]
(R-HSA-9611351)
0.488
2
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