Reactome | SHANK3 [cytosol]

SHANK3 [cytosol]

Stable Identifier

R-HSA-6794277

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SH3 and multiple ankyrin repeat domains protein 3, SHAN3_HUMAN

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External Reference Information

External Reference

UniProt:Q9BYB0 SHANK3

Gene Names

SHANK3, KIAA1650, PROSAP2, PSAP2

Chain

chain:1-1731

Reference Genes

COSMIC (genes):SHANK3 SHANK3

ENSEMBL:ENSG00000283243 SHANK3

HGNC:14294 SHANK3

OMIM:606230 SHANK3

Reference Transcript

RefSeq:NM_033517.1 SHANK3

Participates

as a member of

Inferred To

Shank3 [cytosol] (Mus musculus)

Shank3 [cytosol] (Rattus norvegicus)

Prosap [cytosol] (Drosophila melanogaster)

shn-1 [cytosol] (Caenorhabditis elegans)

SHANK3 [cytosol] (Bos taurus)

SHANK3 [cytosol] (Canis familiaris)

shank3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_277052.1

OpenTargets

ENSG00000251322

GeneCards

Q9BYB0

PRO

Q9BYB0

Pharos - Targets

Q9BYB0

Orphanet

15289

PDB

7C7I, 7C7J, 6CPK

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.573	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.573	2
UniProt:Q9NX63 CHCHD3	3	CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583) CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910)	0.564	2
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.544	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.508	2
UniProt:Q99435 NELL2	1	NELL2 [extracellular region] (R-HSA-9010198)	0.508	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.508	2
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.508	2
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.508	2
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.508	2
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.508	2
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.508	3

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