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SHANK3 [cytosol]
Stable Identifier
R-HSA-6794277
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH3 and multiple ankyrin repeat domains protein 3, SHAN3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Homo sapiens)
RET interactors [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
RET interactors [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
ABP1 binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
HOMER binds SHANK proteins (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
SHANK proteins bind GKAPs (Homo sapiens)
NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
SHARPIN binds SHANK proteins (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
SHARPIN:SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
SHANK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYB0 SHANK3
Gene Names
SHANK3, KIAA1650, PROSAP2, PSAP2
Chain
chain:1-1731
Reference Genes
COSMIC (genes):SHANK3 SHANK3
ENSEMBL:ENSG00000283243 SHANK3
HGNC:14294 SHANK3
OMIM:606230 SHANK3
UCSC:Q9BYB0 SHANK3
Reference Transcript
RefSeq:NM_033517.1 SHANK3
Participates
as a member of
RET interactors [cytosol] (Homo sapiens)
SHANK1,2,3 [cytosol] (Homo sapiens)
Inferred To
Shank3 [cytosol]
(Mus musculus)
Shank3 [cytosol]
(Rattus norvegicus)
Prosap [cytosol]
(Drosophila melanogaster)
shn-1 [cytosol]
(Caenorhabditis elegans)
SHANK3 [cytosol]
(Bos taurus)
SHANK3 [cytosol]
(Canis familiaris)
shank3 [cytosol]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000251322
PRO
Q9BYB0
Pharos - Targets
Q9BYB0
Orphanet
SHANK3
PDB
7C7J
,
7C7I
,
6CPK
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.573
2
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.573
4
UniProt:Q9NX63 CHCHD3
3
CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874907)
4xHC-CHCHD3 [mitochondrial intermembrane space]
(R-HSA-8874910)
CHCHD3 (MIC19) [mitochondrial inner membrane]
(R-HSA-8949583)
0.564
2
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.544
2
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.508
2
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.508
2
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.508
2
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.508
3
UniProt:Q99435 NELL2
1
NELL2 [extracellular region]
(R-HSA-9010198)
0.508
2
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.508
2
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.508
2
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.508
2
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.508
2
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