Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
NMDA receptor complex [plasma membrane]
Stable Identifier
R-HSA-6794308
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDA receptor complex:PSD-95:BEGAIN [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR:PDLIM5 [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDAR binds PSD-95 subfamily members (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
NMDA receptor complex [plasma membrane] (Homo sapiens)
General
NMDAR complex consists of two NR1 subunits and two NR2 subunits. Each subunit has extensive C terminal tail that is modified by series of protein kinases and protein phosphatases. The NR1 subunits binds co-agonist glycine while the NR2 subunit binds glutamate. Hence the activation of NR1/NR2 containing NMDA receptor complexes are activated upon depolarization of the membrane and binding of both glycine and glutamate. The dual requirement of membrane depolarization and agonist binding facilitate coincidence detection by NMDA receptors that ensures activation of both pre-synaptic and post-synaptic cell. NR1/NR2 containing NMDA receptors are highly Ca2+ permeable and subjected to a voltage dependent Mg2+ block.
Literature References
PubMed ID
Title
Journal
Year
17959602
Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly
Bartholomäus, I
,
Mesic, I
,
Laube, B
,
Madry, C
,
Schüler, T
J Biol Chem
2008
Participants
components
GRIN1 [plasma membrane]
(Homo sapiens)
NR2 subunits [plasma membrane]
(Homo sapiens)
Participates
as a component of
NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
as an input of
NMDAR binds PSD-95 subfamily members (Homo sapiens)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text