NRXNs binds MUNC18

Stable Identifier
R-HSA-6794353
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NRXNs binds MUNC18
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The cytoplasmic PDZ (PSD-95, Dlg, and ZO-1/2 domain) domain of Neurexin interacts with the intracellular vesicle trafficking protein MUNC18/STXB1 (syntaxin binding peotein) via a multiprotein complex that involves MINT1 and MINT2. MUNC18, a sec1-like protein that is essential for neurotransmitter release exists in complex with Syntaxin (STX1A) and MINT1 and MINT2 in the nervous system (Okamoto & Sudhof 1997, Biederer & Sudhof 2000).
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Inferred From
Nrxns binds Munc18 (Rattus norvegicus)
Authored
Garapati, P V  (2015-09-04)
Reviewed
Washbourne, P  (2015-11-09)
Created
Garapati, P V  (2015-09-04)
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