Neurexins and neuroligins

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R-HSA-6794361
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Pathway
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Homo sapiens
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Neurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, mediate trans-synaptic signaling, and shape neural network properties by specifying synaptic functions. As cell-adhesion molecules, NRXNs and NLGNs probably function by binding to each other and by interacting with intracellular PDZ-domain proteins, but the precise mechanisms involved and their relation to synaptic transmission remain unclear. The binding of NRXNs and NLGNs to their partners, helps to align the pre-synaptic release machinery and post-synaptic receptors. The importance of neurexins and neuroligins for synaptic function is evident from the dramatic deficits in synaptic transmission in mice lacking Nrxns or Nlgns. In humans, alterations in NRXNs or NLGNs genes are implicated in autism and other cognitive diseases, connecting synaptic cell adhesion to cognition and its disorders (Sudhof 2008, Craig et al. 2006, Craig & Kang 2007).

Literature References
PubMed ID Title Journal Year
22424845 The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses

Krueger, DD, Tuffy, LP, Papadopoulos, T, Brose, N

Curr. Opin. Neurobiol. 2012
23559421 A matter of balance: role of neurexin and neuroligin at the synapse

Bang, ML, Owczarek, S

Neurochem. Res. 2013
17275284 Neurexin-neuroligin signaling in synapse development

Craig, AM, Kang, Y

Curr. Opin. Neurobiol. 2007
21155806 Neurexins, neuroligins and LRRTMs: synaptic adhesion getting fishy

Wright, GJ, Washbourne, P

J. Neurochem. 2011
17299456 Cell adhesion molecules: signalling functions at the synapse

Dalva, MB, McClelland, AC, Kayser, MS

Nat. Rev. Neurosci. 2007
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