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p-S422-SGK1 [cytosol]
Stable Identifier
R-HSA-6795313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
PDPK1 phosphorylates SGK1 (Homo sapiens)
p-S422-SGK1 [cytosol] (Homo sapiens)
TORC2 complex phosphorylates SGK1 (Homo sapiens)
p-S422-SGK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00141 SGK1
Gene Names
SGK1, SGK
Chain
chain:1-431
Reference Genes
BioGPS Gene:6446 SGK1
COSMIC (genes):SGK1 SGK1
CTD Gene:6446 SGK1
dbSNP Gene:6446 SGK1
ENSEMBL:ENSG00000118515 SGK1
HGNC:10810 SGK1
KEGG Gene (Homo sapiens):6446 SGK1
Monarch:6446 SGK1
NCBI Gene:6446 SGK1
OMIM:602958 SGK1
UCSC:O00141 SGK1
Reference Transcript
RefSeq:NM_005627.3 SGK1
RefSeq:NM_001143678.1 SGK1
RefSeq:NM_001143676.1 SGK1
RefSeq:NM_001143677.1 SGK1
RefSeq:NM_001291995.1 SGK1
RefSeq:XM_011536071.1 SGK1
Other Identifiers
0000450148
11715931_s_at
11733698_s_at
11737749_a_at
11737750_s_at
201739_at
2975015
2975016
2975018
2975021
2975023
2975024
2975026
2975027
2975029
2975031
2975033
2975035
2975037
2975040
2975041
2975042
2975043
2975044
2975045
2975046
2975047
2975054
2975069
2975070
2975077
2975078
6446
8129677
973_at
A_23_P19673
GE55129
GO:0000166
GO:0000902
GO:0001558
GO:0003013
GO:0003674
GO:0004672
GO:0004674
GO:0004712
GO:0005246
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006814
GO:0006915
GO:0006950
GO:0006974
GO:0007165
GO:0007616
GO:0008150
GO:0008217
GO:0008219
GO:0008283
GO:0008289
GO:0009058
GO:0015459
GO:0016020
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0017080
GO:0017081
GO:0018105
GO:0030154
GO:0030334
GO:0032411
GO:0034220
GO:0034641
GO:0035091
GO:0035556
GO:0040007
GO:0040011
GO:0042127
GO:0042981
GO:0043167
GO:0043226
GO:0048812
GO:0048856
GO:0048870
GO:0050790
GO:0050877
GO:0051090
GO:0055085
GO:0060453
GO:0070294
ILMN_1702487
ILMN_1853711
ILMN_3229324
ILMN_3305938
PH_hs_0015329
TC06002126.hg
Y10032_at
g5032090_3p_at
Participant Of
output
TORC2 complex phosphorylates SGK1
input
PDPK1 phosphorylates SGK1
Other forms of this molecule
p-T256,S422-SGK1 [nucleoplasm]
SGK1 [cytosol]
p-T256,S422-SGK1 [cytosol]
Inferred To
phospho-sck1 [cytosol] (Schizosaccharomyces pombe)
phospho-sgk-1 [cytosol] (Caenorhabditis elegans)
phospho-p-S422-SGK1 [cytosol] (Dictyostelium discoideum)
phospho-p-S422-SGK1 [cytosol] (Gallus gallus)
phospho-YPK1 [cytosol] (Saccharomyces cerevisiae)
Homologues of p-S422-SGK1 [cytosol] (Dictyostelium discoideum)
Homologues of p-S422-SGK1 [cytosol] (Saccharomyces cerevisiae)
Homologues of p-S422-SGK1 [cytosol] (Schizosaccharomyces pombe)
phospho-Sgk1 [cytosol] (Mus musculus)
phospho-Sgk1 [cytosol] (Rattus norvegicus)
phospho-sck2 [cytosol] (Schizosaccharomyces pombe)
phospho-sgk1 [cytosol] (Danio rerio)
phospho-sgk1 [cytosol] (Xenopus tropicalis)
phospho-pkbA [cytosol] (Dictyostelium discoideum)
phospho-SGK1 [cytosol] (Canis familiaris)
phospho-SGK1 [cytosol] (Sus scrofa)
phospho-SCH9 [cytosol] (Saccharomyces cerevisiae)
Modified Residues
Name
O-phospho-L-serine at 422
Coordinate
422
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001137148.1
,
NP_001137150.1
,
XP_011534373.1
,
NP_001278924.1
,
NP_005618.2
,
NP_001137149.1
OpenTargets
ENSG00000118515
ZINC - Substances
SGK1_HUMAN
HPA
ENSG00000118515-SGK1
GeneCards
O00141
Ensembl
ENST00000528577
,
ENSP00000237305
,
ENSP00000396242
,
ENSP00000434450
,
ENSP00000356831
,
ENST00000413996
,
ENSP00000356832
,
ENST00000237305
,
ENSG00000118515
,
ENST00000367858
,
ENST00000367857
ZINC target
O00141
PRO
O00141
ZINC - Predictions - Purchasable
SGK1_HUMAN
HMDB Protein
HMDBP01258
PDB
3HDN
,
2R5T
,
3HDM
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49815 TSC2
4
p-S939,T1462-TSC2 [cytosol]
(R-HSA-199484)
p-S939,S1130,T1462-TSC2 [cytosol]
(R-HSA-165164)
TSC2 [cytosol]
(R-HSA-2980548)
p-S1387-TSC2 [cytosol]
(R-HSA-3132769)
0.591
4
UniProt:Q9ULP0-2 NDRG4
0.556
3
UniProt:Q969L2 MAL2
0.556
3
UniProt:O15182 CETN3
0.556
3
UniProt:Q80UE6
1
Wnk4 [cytosol]
(R-MMU-2672392)
0.544
2
UniProt:Q9UI14 PRAF1
0.488
2
UniProt:P16220 CREB1
2
CREB1 [nucleoplasm]
(R-HSA-52777)
p-S133-CREB1 [nucleoplasm]
(R-HSA-111910)
0.488
2
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