SGK1 phosphorylates MDM2

Stable Identifier
R-HSA-6795460
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SGK1 phosphorylates MDM2 at serine residues S166 and S188, resulting in MDM2 activation (Amato et al. 2009, Lyo et al. 2010). SGK1 may play a more prominent role in MDM2 activation than AKT (Lyo et al. 2010).

Literature References
PubMed ID Title Journal Year
19756449 Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation

Amato, R, D'Antona, L, Porciatti, G, Agosti, V, Menniti, M, Rinaldo, C, Costa, N, Bellacchio, E, Mattarocci, S, Fuiano, G, Soddu, S, Paggi, MG, Lang, F, Perrotti, N

J. Mol. Med. 2009
20438709 Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway

Lyo, D, Xu, L, Foster, DA

Biochem. Biophys. Res. Commun. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T256,S422-SGK1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed