Reactome: A Curated Pathway Database

SGK1 phosphorylates MDM2

Stable Identifier
R-HSA-6795460
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SGK1 phosphorylates MDM2 at serine residues S166 and S188, resulting in MDM2 activation (Amato et al. 2009, Lyo et al. 2010). SGK1 may play a more prominent role in MDM2 activation than AKT (Lyo et al. 2010).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-T256,S422-SGK1 [cytosol] p-T256,S422-SGK1 [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events