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SGK1 phosphorylates MDM2

Stable Identifier
R-HSA-6795460
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SGK1 phosphorylates MDM2 at serine residues S166 and S188, resulting in MDM2 activation (Amato et al. 2009, Lyo et al. 2010). SGK1 may play a more prominent role in MDM2 activation than AKT (Lyo et al. 2010).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T256,S422-SGK1 [cytosol]
Physical Entity
Activity
Orthologous Events