Reactome: A Curated Pathway Database

PDPK1 phosphorylates SGK1

Stable Identifier
R-HSA-6795473
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PDPK1 (PDK1) activates SGK1 by phosphorylating threonine residue T256, located in the activation loop of SGK1. Phosphorylation of SGK1 at S422 facilitates subsequent phosphorylation at T256 (Kobayashi and Cohen 1999).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane] PDPK1:PIP3 [plasma membrane] protein serine/threonine kinase activity (0004674)
Orthologous Events