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CDK12 [nucleoplasm]
Stable Identifier
R-HSA-6797012
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cyclin-dependent kinase 12, CRK7, CRKRS, Cdc2-related kinase, arginine/serine-rich, CDC2-related protein kinase 7
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
CCNK binds CDK12 (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
CDK12 stimulates expression of DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
CDK12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYV4 CDK12
Gene Names
CDK12, CRK7, CRKRS, KIAA0904
Chain
chain:1-1490
Reference Genes
BioGPS Gene:51755 CDK12
COSMIC (genes):CDK12 CDK12
CTD Gene:51755 CDK12
dbSNP Gene:51755 CDK12
ENSEMBL:ENSG00000167258 CDK12
HGNC:24224 CDK12
KEGG:hsa:51755 CDK12
Monarch:51755 CDK12
NCBI Gene:51755 CDK12
OMIM:615514 CDK12
UCSC:Q9NYV4 CDK12
Reference Transcript
RefSeq:NM_015083.2 CDK12
RefSeq:NM_016507.3 CDK12
Other Identifiers
11739636_s_at
11739637_a_at
11739638_s_at
11739639_at
11745432_a_at
11751936_a_at
1556654_PM_at
1556654_at
1556655_PM_s_at
1556655_s_at
16833750
213557_PM_at
213557_at
219226_PM_at
219226_at
225690_PM_at
225690_at
225691_PM_at
225691_at
225694_PM_at
225694_at
225697_PM_at
225697_at
3720229
3720230
3720231
3720232
3720233
3720234
3720235
3720237
3720238
3720239
3720240
3720241
3720246
3720247
3720248
3720249
3720250
3720252
3720254
3720255
3720257
3720258
3720259
3720260
3720261
3720262
3720263
3720265
3720267
3720268
3720269
3720270
3720272
3720273
3720276
3720288
3720289
3720290
3720293
3720295
37772_at
43064_at
51755
56997_at
58973_at
8006850
81190_at
88666_at
A_14_P106611
A_14_P110415
A_21_P0009243
A_24_P198820
A_33_P3315801
GE54987
GE848870
GO:0002944
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0006366
GO:0006397
GO:0006468
GO:0008024
GO:0008353
GO:0008380
GO:0016071
GO:0016607
GO:0016740
GO:0019901
GO:0019908
GO:0030332
GO:0032968
GO:0043226
GO:0043405
GO:0045944
GO:0046777
GO:0051726
GO:0106310
GO:0140096
GO:2000737
HMNXSV003003122
HMNXSV003007044
HMNXSV003024082
Hs.123073.1.S1_3p_at
Hs.123073.1.S2_3p_at
Hs.123073.1.S3_3p_at
Hs.123073.1.S4_3p_at
Hs.123073.1.S4_3p_x_at
Hs.278346.0.S1_3p_at
Hs2.345028.1.A1_3p_at
ILMN_1707448
PH_hs_0016678
PH_hs_0025043
TC17000474.hg
TC17000475.hg
TC17002190.hg
g7706548_3p_a_at
g7706548_3p_x_at
p20304
p20307
Participates
as a component of
CCNK:CDK12 [nucleoplasm] (Homo sapiens)
as an input of
CCNK binds CDK12 (Homo sapiens)
Inferred To
CDK12 [nucleoplasm]
(Bos taurus)
CDK12 [nucleoplasm]
(Caenorhabditis elegans)
CDK12 [nucleoplasm]
(Canis familiaris)
CDK12 [nucleoplasm]
(Dictyostelium discoideum)
CDK12 [nucleoplasm]
(Drosophila melanogaster)
CDK12 [nucleoplasm]
(Gallus gallus)
CDK12 [nucleoplasm]
(Mus musculus)
CDK12 [nucleoplasm]
(Rattus norvegicus)
CDK12 [nucleoplasm]
(Saccharomyces cerevisiae)
CDK12 [nucleoplasm]
(Schizosaccharomyces pombe)
CDK12 [nucleoplasm]
(Sus scrofa)
CDK12 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of CDK12 [nucleoplasm]
(Danio rerio)
Homologues of CDK12 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of CDK12 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of CDK12 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_055898.1
,
NP_057591.2
Guide to Pharmacology - Targets
1965
OpenTargets
ENSG00000167258
ENSEMBL
ENSP00000407720
,
ENST00000430627
,
ENST00000447079
,
ENSP00000398880
IntEnz
2.7.11.22
,
2.7.11.23
HPA
ENSG00000167258-CDK12
PRO
Q9NYV4
Pharos - Targets
Q9NYV4
GlyGen
Q9NYV4
HMDB Protein
HMDBP01293
PDB
8BUH
,
8BUJ
,
8BUI
,
8BUG
,
8BUB
,
8BU9
,
8BUA
,
8BU7
,
8BU2
,
8BUF
,
6TD3
,
8BUD
,
8BUE
,
8BU1
,
8BUC
,
8P81
,
4UN0
,
8BU4
,
8BU6
,
5ACB
,
6B3E
,
8BU3
,
8BU5
,
4NST
,
6CKX
,
4CXA
,
8BUP
,
8BUR
,
8BUO
,
8BUQ
,
8BUT
,
7NXK
,
8BUS
,
8BUL
,
8BUN
,
8BUK
,
8BUM
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75909 CCNK
1
CCNK [nucleoplasm]
(R-HSA-6796619)
0.688
5
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.643
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.615
3
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.527
2
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.483
2
UniProt:Q8WYQ5 DGCR8
1
DGCR8 [nucleoplasm]
(R-HSA-1482509)
0.483
2
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