Reactome | p-3S-POLR2A [nucleoplasm]

p-3S-POLR2A [nucleoplasm]

Stable Identifier

R-HSA-6797701

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-3S-RPB1

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
        
        p-3S-POLR2A [nucleoplasm] (Homo sapiens)
        
        CDK12 stimulates expression of DNA repair genes (Homo sapiens)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Homo sapiens)
        
        RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
        
        p-3S-POLR2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24928 POLR2A

Gene Names

POLR2A, POLR2

Chain

chain:1-1970

Reference Genes

BioGPS Gene:5430 POLR2A

CTD Gene:5430 POLR2A

dbSNP Gene:5430 POLR2A

ENSEMBL:ENSG00000181222 POLR2A

HGNC:9187 POLR2A

KEGG Gene (Homo sapiens):5430 POLR2A

Monarch:5430 POLR2A

NCBI Gene:5430 POLR2A

OMIM:180660 POLR2A

UCSC:P24928 POLR2A

Reference Transcript

RefSeq:NM_000937.4 POLR2A

Other Identifiers

11747869_a_at

217420_s_at

3708706

3708707

3708709

3708710

3708712

3708714

3708715

3708716

3708717

3708722

3708723

3708724

3708725

5430

A_14_P139348

A_24_P308128

GO:0000398

GO:0000974

GO:0001055

GO:0001172

GO:0003674

GO:0003677

GO:0003723

GO:0003899

GO:0003968

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005665

GO:0005737

GO:0006259

GO:0006283

GO:0006351

GO:0006353

GO:0006355

GO:0006366

GO:0006367

GO:0006368

GO:0006370

GO:0006397

GO:0006950

GO:0007165

GO:0008022

GO:0008150

GO:0008543

GO:0009058

GO:0016032

GO:0016070

GO:0016740

GO:0016779

GO:0019899

GO:0019900

GO:0031625

GO:0032991

GO:0033120

GO:0034641

GO:0035019

GO:0042795

GO:0043167

GO:0043226

GO:0044403

GO:0046872

GO:0050434

GO:0060964

GO:1990841

Hs.171880.1.A1_3p_a_at

Participant Of

hasComponent

RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm]

Other forms of this molecule

p-S2,S7-POLR2A [nucleoplasm]

p-S5,S7-POLR2A [nucleoplasm]

Ub,p-S2,S5-POLR2A [nucleoplasm]

p-S2,S5-POLR2A [nucleoplasm]

p-S5-POLR2A [nucleoplasm]

POLR2A [nucleoplasm]

Inferred To

phospho-p-3S-POLR2A [nucleoplasm] (Bos taurus)

phospho-p-3S-POLR2A [nucleoplasm] (Canis familiaris)

phospho-polr2a [nucleoplasm] (Danio rerio)

phospho-polr2a [nucleoplasm] (Dictyostelium discoideum)

phospho-polr2a [nucleoplasm] (Xenopus tropicalis)

phospho-POLR2A [nucleoplasm] (Sus scrofa)

phospho-rpb1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-Polr2a [nucleoplasm] (Mus musculus)

phospho-Polr2a [nucleoplasm] (Rattus norvegicus)

phospho-RPO21 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-RpII215 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of p-3S-POLR2A [nucleoplasm] (Gallus gallus)

phospho-ama-1 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000928.1

OpenTargets

ENSG00000181222

GeneCards

P24928

HPA

ENSG00000181222-POLR2A

Ensembl

ENSP00000461879, ENST00000572844, ENSG00000181222

PRO

P24928

HMDB Protein

HMDBP00739

PDB

5IYA, 3D9L, 6G0R, 5IYB, 3D9K, 5IYC, 5IYD, 2GHT, 5M3J, 3D9P, 5IY9, 3D9O, 6O9L, 3D9N, 3D9M, 2LTO, 4JXT, 5IY6, 5IY7, 6F5P, 5M3H, 5IY8, 6DRD, 2GHQ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.788	5
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.708	6
UniProt:P23193 TCEA1	1	TCEA1 [nucleoplasm] (R-HSA-65748)	0.708	5
UniProt:P17844 DDX5	4	DDX5 [cytosol] (R-HSA-9682643) DDX5 [nucleoplasm] (R-HSA-3900136) SUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) SUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.641	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.558	6
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.528	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	4
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	8
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.527	2
UniProt:Q03468 ERCC6	2	ERCC6 [nucleoplasm] (R-HSA-54429) Ub-ERCC6 [nucleoplasm] (R-HSA-6781853)	0.499	2