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p-3S-POLR2A [nucleoplasm]
Stable Identifier
R-HSA-6797701
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-3S-RPB1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
p-3S-RNA Pol II:TFIIF [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
p-3S-POLR2A [nucleoplasm] (Homo sapiens)
CDK12 stimulates expression of DNA repair genes (Homo sapiens)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Homo sapiens)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Homo sapiens)
CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Homo sapiens)
p-3S-RNA Pol II:TFIIF [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
p-3S-POLR2A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24928 POLR2A
Gene Names
POLR2A, POLR2
Chain
chain:1-1970
Reference Genes
BioGPS Gene:5430 POLR2A
CTD Gene:5430 POLR2A
dbSNP Gene:5430 POLR2A
ENSEMBL:ENSG00000181222 POLR2A
HGNC:9187 POLR2A
KEGG Gene (Homo sapiens):5430 POLR2A
Monarch:5430 POLR2A
NCBI Gene:5430 POLR2A
OMIM:180660 POLR2A
UCSC:P24928 POLR2A
Reference Transcript
RefSeq:NM_000937.4 POLR2A
Other Identifiers
11747869_a_at
12226
16388
217420_s_at
22311
3708706
3708707
3708709
3708710
3708712
3708714
3708715
3708716
3708717
3708722
3708723
3708724
3708725
5430
A_14_P139348
A_24_P308128
CAB012226
CAB016388
CAB022311
ENSG00000181222
ENSP00000461879
ENST00000572844
ENST00000572844.1
EntrezGene:5430
EntrezGene:POLR2A
GO:0000398
GO:0000974
GO:0001055
GO:0001172
GO:0003674
GO:0003677
GO:0003723
GO:0003899
GO:0003968
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005665
GO:0005737
GO:0006259
GO:0006283
GO:0006351
GO:0006353
GO:0006355
GO:0006366
GO:0006367
GO:0006368
GO:0006370
GO:0006397
GO:0006950
GO:0007165
GO:0008022
GO:0008150
GO:0008543
GO:0009058
GO:0016070
GO:0016740
GO:0016779
GO:0019899
GO:0031625
GO:0032991
GO:0033120
GO:0034641
GO:0035019
GO:0042795
GO:0043167
GO:0043226
GO:0044403
GO:0046872
GO:0050434
GO:0060964
GO:1990841
HGNC:9187
Hs.171880.1.A1_3p_a_at
IPR000722
IPR006592
IPR007066
IPR007080
IPR042102
MIM:180660
PF00623
PF04983
PF04997
POLR2A
POLR2A-201
SM00663
UPI000034E5A7
Participant Of
hasComponent
RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm]
Other forms of this molecule
p-S2,S7-POLR2A [nucleoplasm]
p-S5,S7-POLR2A [nucleoplasm]
Ub,p-S2,S5-POLR2A [nucleoplasm]
POLR2A [nucleoplasm]
p-S5-POLR2A [nucleoplasm]
p-S2,S5-POLR2A [nucleoplasm]
Inferred To
phospho-p-3S-POLR2A [nucleoplasm] (Bos taurus)
phospho-p-3S-POLR2A [nucleoplasm] (Caenorhabditis elegans)
phospho-p-3S-POLR2A [nucleoplasm] (Canis familiaris)
phospho-p-3S-POLR2A [nucleoplasm] (Danio rerio)
phospho-p-3S-POLR2A [nucleoplasm] (Dictyostelium discoideum)
phospho-p-3S-POLR2A [nucleoplasm] (Drosophila melanogaster)
phospho-p-3S-POLR2A [nucleoplasm] (Mus musculus)
phospho-p-3S-POLR2A [nucleoplasm] (Rattus norvegicus)
phospho-p-3S-POLR2A [nucleoplasm] (Saccharomyces cerevisiae)
phospho-p-3S-POLR2A [nucleoplasm] (Schizosaccharomyces pombe)
phospho-p-3S-POLR2A [nucleoplasm] (Sus scrofa)
phospho-p-3S-POLR2A [nucleoplasm] (Xenopus tropicalis)
Ghost homologue of p-3S-POLR2A [nucleoplasm] (Gallus gallus)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_000928.1
OpenTargets
ENSG00000181222
GeneCards
P24928
PRO
P24928
HMDB Protein
HMDBP00739
PDB
2GHQ
,
5IYD
,
3D9P
,
2GHT
,
5IYA
,
6G0R
,
2LTO
,
5M3J
,
5IYC
,
6O9L
,
3D9O
,
5IYB
,
5IY9
,
5M3H
,
3D9N
,
5IY8
,
6DRD
,
3D9L
,
3D9K
,
5IY7
,
6F5P
,
4JXT
,
3D9M
,
5IY6
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.788
5
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.708
6
UniProt:P23193 TCEA1
1
TCEA1 [nucleoplasm]
(R-HSA-65748)
0.708
5
UniProt:P17844 DDX5
3
SUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
DDX5 [nucleoplasm]
(R-HSA-3900136)
SUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.641
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.558
6
UniProt:P19388 POLR2E
2
POLR2E [nucleoplasm]
(R-HSA-83713)
POLR2E [cytosol]
(R-HSA-1964438)
0.528
3
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
8
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.527
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
4
UniProt:Q03468 ERCC6
2
ERCC6 [nucleoplasm]
(R-HSA-54429)
Ub-ERCC6 [nucleoplasm]
(R-HSA-6781853)
0.499
2
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