TP53 inhibits BIRC5 expression

Stable Identifier
R-HSA-6797763
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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Upon binding to the p53 response element in the promoter of the BIRC5 (survivin) gene, TP53 (p53) inhibits transcription of BIRC5, an inhibitor of apoptosis (Hoffman et al. 2002).

Literature References
PubMed ID Title Journal Year
11714700 Transcriptional repression of the anti-apoptotic survivin gene by wild type p53

Hoffman, WH, Biade, S, Zilfou, JT, Chen, J, Murphy, M

J. Biol. Chem. 2002
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