Reactome | TP53 stimulates BNIP3L expression

TP53 stimulates BNIP3L expression

Stable Identifier

R-HSA-6798004

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, mitochondrial outer membrane

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates BNIP3L expression (Homo sapiens)

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TP53 (p53) and CREBBP (CBP) bound to the BNIP3L gene stimulate expression of the BNIP3L. BNIP3L is an outer mitochondrial membrane protein that belongs to the BCL2 family and promotes apoptosis of cells under hypoxic stress (Fei et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15607964	Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth Fei, P, Wang, W, Kim, SH, Wang, S, Burns, TF, Sax, JK, Buzzai, M, Dicker, DT, McKenna, WG, Bernhard, EJ, El-Deiry, WS	Cancer Cell	2004