TP53 stimulates BTG2 expression

Stable Identifier
R-HSA-6798031
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon binding to the p53 response element in the promoter of the BTG2 gene, TP53 induces expression of BTG2 (Rouault et al. 1996, Duriez et al. 2002).

Literature References
PubMed ID Title Journal Year
8944033 Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

Rouault, JP, Falette, N, Guéhenneux, F, Guillot, C, Rimokh, R, Wang, Q, Berthet, C, Moyret-Lalle, C, Savatier, P, Pain, B, Shaw, P, Berger, R, Samarut, J, Magaud, JP, Ozturk, M, Samarut, C, Puisieux, A

Nat. Genet. 1996
11814693 The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene

Duriez, C, Falette, N, Audoynaud, C, Moyret-Lalle, C, Bensaad, K, Courtois, S, Wang, Q, Soussi, T, Puisieux, A

Gene 2002
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created