Reactome: A Curated Pathway Database

Choline catabolism

Stable Identifier
R-HSA-6798163
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Choline is an essential water-soluble nutrient in humans, serving as a precursor of phospholipids and the neurotransmitter acetylcholine. It is often associated with B vitamins based on its chemical structure but it isn't an official B vitamin. Its oxidation to betaine provides a link to folate-dependent, one-carbon metabolism where betaine is a methyl donor in the methionine cycle. Betaine is further metabolised to dimethylglycine which is cleared by the kidney (Ueland 2011, Hollenbeck 2012).

Literature References
PubMed ID Title Journal Year
20446114 Choline and betaine in health and disease J. Inherit. Metab. Dis. 2011
22483274 An introduction to the nutrition and metabolism of choline Cent Nerv Syst Agents Med Chem 2012
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database