TP53 and E2F4 inhibit CDC25C expression

Stable Identifier
R-HSA-6798268
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of TP53 and the E2F4 repressor complex to the promoter of the CDC25C gene results in the inhibition of CDC25C transcription, an important step in the maintenance of the G2 cell cycle checkpoint (St. Clair et al. 2004, Benson et al. 2014).

Literature References
PubMed ID Title Journal Year
15574328 DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter

St Clair, S, Giono, L, Varmeh-Ziaie, S, Resnick-Silverman, L, Liu, WJ, Padi, A, Dastidar, J, DaCosta, A, Mattia, M, Manfredi, JJ

Mol. Cell 2004
24096481 p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

Benson, EK, Mungamuri, SK, Attie, O, Kracikova, M, Sachidanandam, R, Manfredi, JJ, Aaronson, SA

Oncogene 2014
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