GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC

Stable Identifier
R-HSA-6798317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic glycine N-methyltransferase (GNMT) catalyses the transfer of a methyl group from S-adenosylmethionine (AdoMet) to glycine (Gly) to form sarcosine (SARC, aka N-methylglycine) with the concomitant production of S-adenosylhomocysteine (AdoHcy) (Pakhomova et al. 2004).

Literature References
PubMed ID Title Journal Year
15340920 Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes

Pakhomova, S, Luka, Z, Grohmann, S, Wagner, C, Newcomer, ME

Proteins 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycine N-methyltransferase activity of GNMT tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created