Reactome: A Curated Pathway Database

BPGM dimer isomerises 1,3BPG to 2,3BPG

Stable Identifier
R-HSA-6798335
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific trifunctional enzyme. One of its functions is the isomerisation of 1,3-bisphosphoglycerate (1,3BPG) to 2,3-bisphosphoglycerate (2,3BPG) (Rose 1968). In red blood cells, 2,3BPG is the main allosteric effector of hemoglobin, binding preferentially to the deoxygenated hemoglobin tetramer, thus reducing oxygen affinity (Arnone 1972).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
bisphosphoglycerate mutase activity of BPGM dimer [cytosol] BPGM dimer [cytosol] bisphosphoglycerate mutase activity (0004082)
Orthologous Events