Reactome | S100A8:S100A9:Ca2+:Mn2+:Na+ [extracellular region]

Stable Identifier

R-HSA-6798411

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Synonyms

calprotectin heterotetramer

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
23431180	Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens Hench, L, Skaar, EP, Sugitani, N, Fritz, G, Betz, C, Zhang, Y, Rathi, S, Damo, SM, Kehl-Fie, TE, Chazin, WJ, Murphy, WJ, Holt, ME	Proc. Natl. Acad. Sci. U.S.A.	2013
25597447	Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis Nolan, EM, Brophy, MB, Drennan, CL, Gagnon, DM, Britt, RD, Stich, TA, Bowman, SE	J. Am. Chem. Soc.	2015
17553524	The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins Skerra, A, Brueckner, F, Korndörfer, IP	J. Mol. Biol.	2007

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