ZNF420 binds TP53AIP1 gene

Stable Identifier
R-HSA-6798624
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The transcription factor ZNF420 (Apak) has a binding site in the first intron of the TP53AIP1 gene that overlaps with the p53 response element. The binding of ZNF420 interferes with the binding of TP53 and results in the repression of TP53AIP1 transcription (Yuan et al. 2012).

Literature References
PubMed ID Title Journal Year
22334068 Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis

Yuan, L, Tian, C, Wang, H, Song, S, Li, D, Xing, G, Yin, Y, He, F, Zhang, L

EMBO Rep. 2012
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