Reactome | RPS4X [nucleoplasm]

RPS4X [nucleoplasm]

Stable Identifier

R-HSA-6798713

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein 4, P12750, 40S ribosomal protein S4, X isoform, Single copy abundant mRNA protein, SCR10

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P62701 RPS4X

Gene Names

RPS4X, CCG2, RPS4, SCAR

Chain

initiator methionine:, chain:2-263

Reference Genes

BioGPS Gene:6191 RPS4X

COSMIC (genes):RPS4X RPS4X

CTD Gene:6191 RPS4X

dbSNP Gene:6191 RPS4X

ENSEMBL:ENSG00000198034 RPS4X

ENSEMBL_homo_sapiens_GENE:ENSG00000198034.11 RPS4X

HGNC:10424 RPS4X

KEGG Gene (Homo sapiens):6191 RPS4X

Monarch:6191 RPS4X

NCBI Gene:6191 RPS4X

OMIM:312760 RPS4X

UCSC:P62701 RPS4X

Reference Transcript

RefSeq:NM_001007.4 RPS4X

Other Identifiers

11757780_x_at

17112005

200933_3p_x_at

200933_PM_x_at

200933_x_at

213347_3p_x_at

213347_PM_x_at

213347_x_at

2806954

3373987

3373989

34643_at

3467630

4012157

4012158

4012159

4012160

4012162

4012163

4012165

4012168

4012169

4012170

4012171

4012172

4012173

6191

8173513

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0008284

GO:0015935

GO:0016020

GO:0019843

GO:0022626

GO:0022627

GO:0032040

GO:0036464

GO:0042254

GO:0042274

GO:0043226

GO:0045202

GO:0045727

GO:0070062

GO:1990904

HMNXSV003044761

Hs.108124.5.A1_3p_a_at

Hs.108124.5.A1_3p_x_at

ILMN_1810577

ILMN_2166831

PH_hs_0030329

TC0X001138.hg

g4506724_3p_a_at

Participates

as a member of

RPS4X,RPS4Y1,RPS4Y2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS4X [cytosol]

Inferred To

RPS4 [nucleoplasm] (Bos taurus)

RPS4 [nucleoplasm] (Gallus gallus)

Homologues of RPS4X [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPS4X [nucleoplasm] (Schizosaccharomyces pombe)

RPS4B [nucleoplasm] (Saccharomyces cerevisiae)

rps-4 [nucleoplasm] (Caenorhabditis elegans)

rps402 [nucleoplasm] (Schizosaccharomyces pombe)

rps4 [nucleoplasm] (Dictyostelium discoideum)

rps4 [nucleoplasm] (Xenopus tropicalis)

rps401 [nucleoplasm] (Schizosaccharomyces pombe)

Rps4x [nucleoplasm] (Mus musculus)

Rps4x [nucleoplasm] (Rattus norvegicus)

RPS4A [nucleoplasm] (Saccharomyces cerevisiae)

RPS4X [nucleoplasm] (Canis familiaris)

RPS4X [nucleoplasm] (Plasmodium falciparum)

RPS4X [nucleoplasm] (Sus scrofa)

rps4x [nucleoplasm] (Danio rerio)

RpS4 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_000998.1

OpenTargets

ENSG00000198034

HPA

ENSG00000198034-RPS4X

GeneCards

P62701

Ensembl

ENST00000316084, ENSG00000198034, ENSP00000362744

PRO

P62701

Pharos - Targets

P62701

PDB

6ZVH, 6ZM7, 6ZOJ, 6ZVJ, 8IFD, 7K5I, 7A09, 6ZOK, 6YBW, 6OM7, 8Y0X, 8Y0W, 8G6J, 8IFE, 6G53, 7XNX, 7XNY, 7WTS, 8OZ0, 6ZUO, 6ZME, 7WTT, 6G51, 6ZP4, 7MQ8, 6QZP, 6IP8, 5VYC, 6OM0, 7TQL, 6G4S, 6ZXH, 7R4X, 6IP6, 8JDL, 6FEC, 7MQA, 6IP5, 8T4S, 8JDM, 7WTX, 6Z6L, 6ZLW, 8GLP, 7WTZ, 7WU0, 6Y57, 8PPK, 8PPL, 6ZMW, 6ZXD, 6ZN5, 6ZXE, 6Z6N, 4V6X, 7QP6, 6Y2L, 6ZON, 6ZXF, 6ZXG, 7QP7, 6G4W, 6Y0G, 8JDJ, 5T2C, 5LKS, 6G18, 6ZMI, 6ZV6, 4UG0, 7WTU, 8G61, 6OLI, 7WTV, 8G5Y, 8G60, 5OA3, 8JDK, 6G5I, 6G5H, 6XA1, 6ZMO, 7QVP, 7WTW, 6OLF, 6Z6M, 5A2Q, 6OLE, 6ZMT

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.69	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	5
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2

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