Reactome | RPS12 [nucleoplasm]

RPS12 [nucleoplasm]

Stable Identifier

R-HSA-6798715

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S small ribosomal protein 12, P25398, 40S ribosomal protein S12

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P25398 RPS12

Gene Names

RPS12

Chain

initiator methionine:, chain:2-132

Reference Genes

BioGPS Gene:6206 RPS12

COSMIC (genes):RPS12 RPS12

CTD Gene:6206 RPS12

dbSNP Gene:6206 RPS12

ENSEMBL:ENSG00000112306 RPS12

ENSEMBL_homo_sapiens_GENE:ENSG00000112306.8 RPS12

HGNC:10385 RPS12

KEGG Gene (Homo sapiens):6206 RPS12

Monarch:6206 RPS12

NCBI Gene:6206 RPS12

OMIM:603660 RPS12

UCSC:P25398 RPS12

Reference Transcript

RefSeq:NM_001016.3 RPS12

Other Identifiers

11753637_x_at

11757023_x_at

213377_PM_x_at

213377_x_at

2771027

2926207

2926208

2926210

2926216

2926218

2926222

2979632

3284810

33116_f_at

33117_r_at

6206

64360_f_at

8122136

A_23_P82128

GE78958

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005794

GO:0005829

GO:0005840

GO:0006412

GO:0016020

GO:0022626

GO:0022627

GO:0023052

GO:0032040

GO:0042254

GO:0042274

GO:0043226

GO:0043231

GO:0090263

GO:1990904

HMNXSV003050835

Hs.285405.2.S1_3p_s_at

ILMN_1782621

TC06000996.hg

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RPS12 [cytosol]

Inferred To

rps-12 [nucleoplasm] (Caenorhabditis elegans)

RPS12 [nucleoplasm] (Bos taurus)

RPS12 [nucleoplasm] (Canis familiaris)

RPS12 [nucleoplasm] (Gallus gallus)

RPS12 [nucleoplasm] (Plasmodium falciparum)

RPS12 [nucleoplasm] (Saccharomyces cerevisiae)

RPS12 [nucleoplasm] (Sus scrofa)

rps1202 [nucleoplasm] (Schizosaccharomyces pombe)

rps12 [nucleoplasm] (Danio rerio)

rps12 [nucleoplasm] (Dictyostelium discoideum)

rps12 [nucleoplasm] (Xenopus tropicalis)

rps1201 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of RPS12 [nucleoplasm] (Schizosaccharomyces pombe)

Rps12 [nucleoplasm] (Mus musculus)

Rps12l8 [nucleoplasm] (Rattus norvegicus)

RpS12 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001007.2

OpenTargets

ENSG00000112306

GeneCards

P25398

HPA

ENSG00000112306-RPS12

Ensembl

ENSG00000112306, ENSP00000230050, ENST00000230050

PRO

P25398

Pharos - Targets

P25398

PDB

6QZP, 6ZVJ, 8IFD, 6ZMI, 6OLF, 6G18, 6ZVH, 7A09, 6G51, 6ZMO, 7WTW, 7QP6, 6OLG, 6YBS, 6ZMT, 6ZXF, 7R4X, 7WTX, 6Y57, 5OA3, 6ZMW, 6ZXH, 6ZUO, 6ZLW, 8PPL, 6XA1, 8G5Y, 8G60, 5T2C, 6G5H, 7WTT, 8OZ0, 6OLE, 5VYC, 5FLX, 7WTV, 8GLP, 8T4S, 6ZXD, 8IFE, 6IP5, 6G5I, 6OM7, 6ZOJ, 7TQL, 5A2Q, 7QP7, 6IP6, 6ZXE, 8PPK, 5LKS, 6ZOL, 7WTZ, 8G6J, 7MQ8, 6G53, 7WU0, 7MQ9, 6Z6L, 6IP8, 4V6X, 6ZN5, 6ZXG, 6ZON, 6Z6M, 7MQA, 6OLI, 7XNX, 6ZM7, 7XNY, 6Z6N, 6ZP4, 6ZV6, 6FEC, 8G61, 5AJ0, 6ZME, 7WTU, 7K5I, 6OLZ, 6OM0, 6Y0G

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	18
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:P09429 HMGB1	5	HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [nucleoplasm] (R-HSA-266221) HC23,45-HMGB1 [extracellular region] (R-HSA-6797422)	0.482	2

Cite Us!