Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Exocytosis of azurophil granule membrane proteins
Stable Identifier
R-HSA-6798739
Type
Reaction [transition]
Species
Homo sapiens
Compartment
azurophil granule membrane
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule membrane proteins (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Azurophil or primary granules were originally defined by their high content of myeloperoxidase (MPO) and their affinity for the basic dye azure A (Spicer & Hardin 1969). Azurophil granules are generally described as spherical. Like lysosomes, they contain CD63 in their membrane (Cham et al. 1994) but are regarded as specialized secretory granules rather than lysosomes (Cieutat et al. 1998). Azurophil granules undergo limited exocytosis in response to stimulation (Sengelov et al. 1993, Faurschou et al. 2002), their primary role is believed to be killing and degradation of engulfed microbes in the phagolysosome (Joiner et al. 1989).
Literature References
PubMed ID
Title
Journal
Year
8692836
Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells
Le Cabec, V
,
Borregaard, N
,
Calafat, J
,
Cowland, JB
Proc. Natl. Acad. Sci. U.S.A.
1996
Participants
Input
Azurophil granule membrane proteins [azurophil granule membrane]
(Homo sapiens)
Output
Azurophil granule membrane proteins [plasma membrane]
(Homo sapiens)
Participates
as an event of
Neutrophil degranulation (Homo sapiens)
Orthologous Events
Exocytosis of azurophil granule membrane proteins (Bos taurus)
Exocytosis of azurophil granule membrane proteins (Caenorhabditis elegans)
Exocytosis of azurophil granule membrane proteins (Canis familiaris)
Exocytosis of azurophil granule membrane proteins (Danio rerio)
Exocytosis of azurophil granule membrane proteins (Dictyostelium discoideum)
Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)
Exocytosis of azurophil granule membrane proteins (Gallus gallus)
Exocytosis of azurophil granule membrane proteins (Mus musculus)
Exocytosis of azurophil granule membrane proteins (Plasmodium falciparum)
Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)
Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)
Exocytosis of azurophil granule membrane proteins (Schizosaccharomyces pombe)
Exocytosis of azurophil granule membrane proteins (Sus scrofa)
Exocytosis of azurophil granule membrane proteins (Xenopus tropicalis)
Authored
Jupe, S (2015-09-21)
Reviewed
Heegaard, N (2016-06-13)
Created
Jupe, S (2015-09-21)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text