Exocytosis of tertiary granule lumen proteins

Stable Identifier
R-HSA-6798745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
tertiary granule lumen, extracellular region
ReviewStatus
5/5
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Exocytosis of tertiary granule lumen proteins
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Tertiary (gelatinase) granules are part of a continuum of peroxidase-negative granules formed in myelocytes, metamyelocytes, band cells and segmented neutrophils. They differ from secondary granules by having a low content of antimicrobial substances, and are more readily exocytosed (Sengelov et al. 1995). Tertiary granules are primarily a reservoir of extracellular matrix degrading enzymes and membrane receptors that are needed for neutrophil extravasation and diapedesis (Faurschou & Borregaard 2003).
Literature References
PubMed ID Title Journal Year
23650620 Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

Heegaard, NH, Rørvig, S, Borregaard, N, Østergaard, O

J. Leukoc. Biol. 2013
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Orthologous Events
Exocytosis of tertiary granule lumen proteins (Bos taurus)
Exocytosis of tertiary granule lumen proteins (Caenorhabditis elegans)
Exocytosis of tertiary granule lumen proteins (Canis familiaris)
Exocytosis of tertiary granule lumen proteins (Danio rerio)
Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)
Exocytosis of tertiary granule lumen proteins (Drosophila melanogaster)
Exocytosis of tertiary granule lumen proteins (Gallus gallus)
Exocytosis of tertiary granule lumen proteins (Mus musculus)
Exocytosis of tertiary granule lumen proteins (Plasmodium falciparum)
Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)
Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)
Exocytosis of tertiary granule lumen proteins (Schizosaccharomyces pombe)
Exocytosis of tertiary granule lumen proteins (Sus scrofa)
Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)
Authored
Jupe, S  (2015-09-21)
Reviewed
Heegaard, N  (2016-06-13)
Created
Jupe, S  (2015-09-21)
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