Exocytosis of tertiary granule lumen proteins

Stable Identifier
R-HSA-6798745
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Tertiary (gelatinase) granules are part of a continuum of peroxidase-negative granules formed in myelocytes, metamyelocytes, band cells and segmented neutrophils. They differ from secondary granules by having a low content of antimicrobial substances, and are more readily exocytosed (Sengelov et al. 1995). Tertiary granules are primarily a reservoir of extracellular matrix degrading enzymes and membrane receptors that are needed for neutrophil extravasation and diapedesis (Faurschou & Borregaard 2003).

Literature References
PubMed ID Title Journal Year
23650620 Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

Rørvig, S, Østergaard, O, Heegaard, NH, Borregaard, N

J. Leukoc. Biol. 2013
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Orthologous Events
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