Exocytosis of secretory granule lumen proteins

Stable Identifier
R-HSA-6798748
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Secretory vesicles provide a reservoir of secreted proteins and membrane-associated receptors that are required at the earliest stages of the neutrophil-mediated inflammatory response. They are mobilized in response to a wide variety of inflammatory stimuli (Sengelov et al. 1993a,b). Resultant cell surface changes allow the neutrophil to establish firm contact with activated vascular epithelium (Faurschou & Borregaard 2003).

Literature References
PubMed ID Title Journal Year
23650620 Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

Rørvig, S, Østergaard, O, Heegaard, NH, Borregaard, N

J. Leukoc. Biol. 2013
Participants
Participant Of
Orthologous Events
Authored
Reviewed