Reactome | p-S68-ZNF420 [nucleoplasm]

p-S68-ZNF420 [nucleoplasm]

Stable Identifier

R-HSA-6799095

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S68=Apak

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        ATM phosphorylates ZNF420 (Homo sapiens)
        
        p-S68-ZNF420 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8TAQ5 ZNF420

Gene Names

ZNF420

Chain

chain:1-688

Reference Genes

BioGPS Gene:147923 ZNF420

COSMIC (genes):ZNF420 ZNF420

CTD Gene:147923 ZNF420

dbSNP Gene:147923 ZNF420

ENSEMBL:ENSG00000197050 ZNF420

HGNC:20649 ZNF420

KEGG Gene (Homo sapiens):147923 ZNF420

Monarch:147923 ZNF420

NCBI Gene:147923 ZNF420

UCSC:Q8TAQ5 ZNF420

Reference Transcript

Other Identifiers

0006840722

11744188_at

147923

16861500

238937_at

242761_s_at

3831699

3831703

3831704

3831705

3831707

3831708

3831709

3831710

3831711

3831712

3831713

3831714

3831715

3831716

3831717

3831718

3831719

3831720

3831721

3831722

3831723

3831724

3871911

64224_at

76767_at

8028219

A_14_P105591

A_23_P380951

A_33_P3395389

A_33_P3395396

GE477890

GO:0003674

GO:0003676

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006355

GO:0008150

GO:0008219

GO:0009058

GO:0034641

GO:0042981

GO:0043167

GO:0043226

GO:0046872

Hs.133437.0.A1_3p_at

Hs.31511.0.A1_3p_at

ILMN_1720431

PH_hs_0008035

TC19000511.hg

Participant Of

output

ATM phosphorylates ZNF420

Other forms of this molecule

ZNF420 [nucleoplasm]

Inferred To

Homologues of p-S68-ZNF420 [nucleoplasm] (Bos taurus)

phospho-Zfp420 [nucleoplasm] (Mus musculus)

phospho-Zfp420 [nucleoplasm] (Rattus norvegicus)

phospho-p-S68-ZNF420 [nucleoplasm] (Bos taurus)

phospho-p-S68-ZNF420 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S68-ZNF420 [nucleoplasm] (Canis familiaris)

phospho-p-S68-ZNF420 [nucleoplasm] (Sus scrofa)

phospho-wek [nucleoplasm] (Drosophila melanogaster)

phospho-TFIIIA [nucleoplasm] (Dictyostelium discoideum)

phospho-ZNF384 [nucleoplasm] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 68

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001316451.1, XP_011524806.1, XP_011524805.1, NP_653290.2

OpenTargets

ENSG00000197050

GeneCards

Q8TAQ5

HPA

ENSG00000197050-ZNF420

Ensembl

ENSP00000338770, ENSP00000306102, ENSG00000197050, ENST00000337995, ENST00000304239

PRO

Q8TAQ5

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N726 CDKN2A	12	p14ARF [cytosol] (R-HSA-9645669) p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF R21RfsTER47 [cytosol] (R-HSA-9646285)	0.644	8
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.591	4
UniProt:Q9NX04 CA109			0.556	3
UniProt:Q96LK0 CEP19			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:P36508 ZNF76			0.556	3
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [cytosol] (R-HSA-429889)	0.556	3

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