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Intermediate 1 binds HP subcomplex to form Intermediate 2
Stable Identifier
R-HSA-6799178
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
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The hydrophobic protein fraction (HP) is assembled with NDUFA3, 8, 9 and 13 amongst many others and anchored to the inner mitochondrial membrane by Intermediate 1 assembly factors NDUFAF3 (C3orf60), NDUFAF4 (C6orf66) and TIMMDC1 (C3orf1) to form Intermediate 2 (Mckenzie & Ryan 2010, Andrews et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
20552642
Assembly factors of human mitochondrial complex I and their defects in disease
Ryan, MT
,
McKenzie, M
IUBMB Life
2010
24191001
Assembly factors for the membrane arm of human complex I
Fearnley, IM
,
Carroll, J
,
Andrews, B
,
Walker, JE
,
Ding, S
Proc. Natl. Acad. Sci. U.S.A.
2013
Participants
Input
HP subcomplex [mitochondrial inner membrane]
(Homo sapiens)
Intermediate 1 [mitochondrial inner membrane]
(Homo sapiens)
Output
Intermediate 2 [mitochondrial inner membrane]
(Homo sapiens)
Participates
as an event of
Complex I biogenesis (Homo sapiens)
Orthologous Events
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Caenorhabditis elegans)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Gallus gallus)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Sus scrofa)
Authored
Jassal, B (2015-09-22)
Reviewed
Meldal, BH (2015-10-01)
Created
Jassal, B (2015-09-22)
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