CHEK1 phosphorylates TP53

Stable Identifier
R-HSA-6799246
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).

Literature References
PubMed ID Title Journal Year
10673501 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, SY, Ahn, J, Tamai, K, Taya, Y, Prives, C

Genes Dev 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created