Reactome | TTR [azurophil granule lumen]

TTR [azurophil granule lumen]

Stable Identifier

R-HSA-6799366

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Transthyretin, TTHY_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02766 TTR

Gene Names

TTR, PALB

Chain

signal peptide:1-20, chain:21-147

Reference Genes

BioGPS Gene:7276 TTR

COSMIC (genes):TTR TTR

CTD Gene:7276 TTR

dbSNP Gene:7276 TTR

ENSEMBL:ENSG00000118271 TTR

ENSEMBL_homo_sapiens_GENE:ENSG00000118271.12 TTR

HGNC:12405 TTR

KEGG Gene (Homo sapiens):7276 TTR

Monarch:7276 TTR

NCBI Gene:7276 TTR

OMIM:176300 TTR

UCSC:P02766 TTR

Reference Transcript

RefSeq:NM_000371.3 TTR

Other Identifiers

11754285_a_at

16851786

209660_PM_at

209660_at

32252_at

3783578

3783579

3783581

3783587

3783588

3783589

7276

8020795

A_23_P130333

GE80911

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0006144

GO:0007165

GO:0023052

GO:0031410

GO:0035578

GO:0042802

GO:0043226

GO:0048018

GO:0055086

GO:0070062

GO:0070324

GO:0098772

HMNXSV003012754

M15517_cds5_at

PH_hs_0019852

PH_hs_0033292

TC18000129.hg

g5533090_3p_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

TTR [extracellular region]

Inferred To

Homologues of TTR [azurophil granule lumen] (Caenorhabditis elegans)

Homologues of TTR [azurophil granule lumen] (Sus scrofa)

TTR [azurophil granule lumen] (Bos taurus)

TTR [azurophil granule lumen] (Caenorhabditis elegans)

TTR [azurophil granule lumen] (Canis familiaris)

TTR [azurophil granule lumen] (Dictyostelium discoideum)

TTR [azurophil granule lumen] (Drosophila melanogaster)

TTR [azurophil granule lumen] (Gallus gallus)

TTR [azurophil granule lumen] (Mus musculus)

TTR [azurophil granule lumen] (Rattus norvegicus)

TTR [azurophil granule lumen] (Schizosaccharomyces pombe)

TTR [azurophil granule lumen] (Sus scrofa)

TTR [azurophil granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_000362.1

ZINC - World Drugs

TTHY_HUMAN

Guide to Pharmacology - Targets

2851

OpenTargets

ENSG00000118271

ZINC - FDA approved

TTHY_HUMAN

ZINC - Substances

TTHY_HUMAN

ZINC - Biogenic

TTHY_HUMAN

ZINC target

P02766

PRO

P02766

PDB

5AKS, 3IMW, 6D0W, 5L4J, 5K1J, 7Q9O, 1BZD, 4Y9B, 6E78, 2G3Z, 6SDZ, 1DVU, 4IKK, 8PKF, 3CN4, 3IPE, 7YCQ, 8IG1, 1ETB, 7DT5, 4YDN, 3GLZ, 5DWP, 5L4M, 3DJS, 4I87, 3A4F, 5EN3, 7YBR, 5H0Z, 4WNJ, 5FW8, 8W43, 5TZL, 8PKE, 1X7T, 4AC4, 3M1O, 5CM1, 4TNF, 8E7J, 7OB4, 4N86, 3NEX, 4PVM, 3DID, 6R68, 4ABQ, 1TSH, 5N7C, 5FW6, 3I9I, 7ERJ, 5L4F, 5U4B, 1F41, 6FWD, 1TYR, 5NFW, 4L1S, 4QXV, 7THA, 4PME, 4TL5, 7W9R, 4DET, 1DVQ, 4MRC, 4TLS, 1E5A, 3IMU, 5U4F, 3ESN, 4TKW, 1ICT, 4IK7, 3TFB, 1TTR, 3GPS, 3DK0, 4ACT, 6SUH, 1U21, 5N5Q, 8E7E, 1TT6, 8VE0, 3CN2, 4IKL, 3GS7, 5H0W, 2NBP, 4ANK, 4TQP, 8W45, 5EZP, 7EJR, 5U49, 7DT6, 1QWH, 4QYA, 7Q3I, 6E71, 4TL4, 2QGC, 6GRP, 8E7D, 2GAB, 3DK2, 2TRY, 3B56, 5TTR, 1SOK, 3P3T, 3CBR, 6FFT, 1TTA, 1FH2, 4I89, 5DEJ, 5CLY, 1QAB, 8AWW, 1TLM, 4TM9, 5CR1, 4I85, 3A4D, 4WNS, 3KGT, 1BM7, 6TI9, 4IIZ, 5U4D, 6IMX, 3NEO, 5H0X, 4ABV, 3SSG, 5CN3, 6R66, 1IJN, 1X7S, 3IPB, 4TQ8, 5FW7, 1TTB, 5JIM, 4Y9F, 5BOJ, 3IMS, 4PWK, 1THA, 8II2, 4TNG, 1ETA, 5AYT, 6TXV, 3CXF, 6E6Z, 2QGD, 2FLM, 4ABW, 4TLK, 4IKI, 3DO4, 8TDO, 1SOQ, 4TQH, 3GS0, 3NG5, 5LLL, 1Y1D, 1Z7J, 2G9K, 4DER, 3BT0, 1TTC, 5OQ0, 6R6I, 8W47, 3ESO, 3CFT, 3OZK, 1DVY, 6TXW, 1E3F, 3P3R, 3DJT, 4PWF, 4HJU, 6KGB, 2H4E, 4AC2, 8TDN, 5IHH, 2B9A, 1BMZ, 8C86, 1E4H, 6E74, 8E7I, 4FI8, 7W9Q, 2ROY, 4IK6, 8HEJ, 1THC, 5A6I, 7Z60, 8I0O, 8II4, 3A4E, 4TNE, 7Q9N, 8ADE, 4PWG, 6R67, 3CN0, 3IMV, 5CLZ, 5AL8, 4PMF, 2QGB, 7QC5, 6XTK, 2PAB, 5AKT, 8G9R, 7EJQ, 4HJS, 2QEL, 3FC8, 4TLT, 8W42, 4PM1, 8HY4, 1GKO, 4PWH, 2NBO, 5H0V, 6SUG, 8W44, 8AWI, 4D7B, 6FXU, 4Y9G, 2B14, 2G4E, 3GRB, 6E72, 3P3U, 3KGU, 5K1N, 5AKV, 4Y9C, 4PWJ, 1BZE, 4TLU, 6IMY, 3GS4, 5U4C, 1F86, 5L4I, 2FBR, 3NES, 3U2I, 3CFM, 7WL6, 5E4O, 2WQA, 4MAS, 6E73, 5U4G, 7Y1I, 2G4G, 2TRH, 1DVZ, 2B77, 3IMT, 1III, 1RLB, 5N62, 3W3B, 7ERI, 6TJN, 3DJZ, 4KY2, 3D7P, 4FI6, 1BZ8, 7ERK, 3BSZ, 1ZCR, 3KGS, 4PVN, 3CN3, 8II1, 3IMR, 7ACU, 5CLX, 5NFE, 3OZL, 7Q9L, 6E70, 2B16, 3FCB, 7Y6J, 5U4A, 2G5U, 3P3S, 6GR7, 2B15, 8W46, 4HJT, 5U48, 4YDM, 3DJR, 3D2T, 5E23, 4Y9E, 1G1O, 4DEU, 5U4E, 8W48, 6EOY, 4HIQ, 7ERH, 3HJ0, 2F8I, 4PWI, 4QRF, 8I00, 8C85, 4L1T, 8E7H, 1DVS, 6E75, 4N87, 5JIQ, 2F7I, 6FZL, 3CFN, 1ZD6, 4N85, 1TZ8, 5HJG, 4FI7, 5CNH, 3GRG, 4PVL, 5AL0, 2M5N, 1IIK, 4WO0, 4HIS, 5LLV, 1DVX, 3I9A, 6EP1, 5H0Y, 2G3X, 5FO2, 6E76, 2ROX, 3CFQ, 5E4A, 3I9P, 3TCT, 4DES, 3NEE, 2NOY, 1FHN, 3ESP, 3DGD, 2QGE, 4MRB, 4ABU, 6U0Q, 3CN1, 3U2J, 1DVT, 6E77, 8PKG, 4IKJ, 4PWE, 7DT8, 7DT3, 5JID, 4TQI, 8II3, 4DEW

ZINC - Metabolites

TTHY_HUMAN

GeneCards

P02766

HPA

ENSG00000118271-TTR

Ensembl

ENSP00000237014, ENST00000649620, ENST00000237014, ENSP00000497927, ENSG00000118271

Pharos - Targets

P02766

ZINC - Predictions - Purchasable

TTHY_HUMAN

Orphanet

15674

HMDB Protein

HMDBP01831

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.668	3
UniProt:P02753 RBP4	3	RBP4 G75D [extracellular region] (R-HSA-2471928) RBP4 I41N [extracellular region] (R-HSA-2471954) RBP4(19-201) [extracellular region] (R-HSA-2453675)	0.646	4
UniProt:P25713 MT3	1	MT3 [cytosol] (R-HSA-5660396)	0.593	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.558	2
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.556	3
UniProt:Q9Y2D1 ATF5	1	ATF5 [nucleoplasm] (R-HSA-9653719)	0.556	3
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) TDG [nucleoplasm] (R-HSA-65812)	0.556	3
UniProt:Q06136 KDSR	1	KDSR [endoplasmic reticulum membrane] (R-HSA-428134)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523)	0.556	3
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.556	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.553	2
UniProt:P61916 NPC2	3	NPC2 [lysosomal lumen] (R-HSA-8876488) NPC2 [extracellular region] (R-HSA-6806224) NPC2 [azurophil granule lumen] (R-HSA-6799163)	0.527	2

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