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TTR [azurophil granule lumen]
Stable Identifier
R-HSA-6799366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
Transthyretin, TTHY_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
TTR [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02766 TTR
Gene Names
TTR, PALB
Chain
signal peptide:1-20, chain:21-147
Reference Genes
BioGPS Gene:7276 TTR
COSMIC (genes):TTR TTR
CTD Gene:7276 TTR
dbSNP Gene:7276 TTR
ENSEMBL:ENSG00000118271 TTR
HGNC:12405 TTR
KEGG Gene (Homo sapiens):7276 TTR
Monarch:7276 TTR
NCBI Gene:7276 TTR
OMIM:176300 TTR
UCSC:P02766 TTR
Reference Transcript
RefSeq:NM_000371.3 TTR
Other Identifiers
11754285_a_at
16851786
209660_at
32252_at
3783578
3783579
3783581
3783587
3783588
3783589
7276
8020795
A_23_P130333
GE80911
GO:0001523
GO:0002376
GO:0003674
GO:0005179
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005773
GO:0006144
GO:0006629
GO:0006810
GO:0007165
GO:0008150
GO:0016192
GO:0030198
GO:0031410
GO:0032991
GO:0034641
GO:0035578
GO:0042562
GO:0042572
GO:0042802
GO:0043226
GO:0043312
GO:0044267
GO:0044281
GO:0044877
GO:0070062
GO:0070324
GO:0070327
M15517_cds5_at
PH_hs_0019852
PH_hs_0033292
TC18000129.hg
g5533090_3p_at
Participant Of
hasMember
Azurophil granule lumen proteins [azurophil granule lumen]
Other forms of this molecule
TTR [extracellular region]
Inferred To
ttr [azurophil granule lumen] (Danio rerio)
ttr [azurophil granule lumen] (Xenopus tropicalis)
Homologues of TTR [azurophil granule lumen] (Caenorhabditis elegans)
Ttr [azurophil granule lumen] (Mus musculus)
Ttr [azurophil granule lumen] (Rattus norvegicus)
TTR [azurophil granule lumen] (Caenorhabditis elegans)
TTR [azurophil granule lumen] (Canis familiaris)
TTR [azurophil granule lumen] (Dictyostelium discoideum)
TTR [azurophil granule lumen] (Gallus gallus)
TTR [azurophil granule lumen] (Schizosaccharomyces pombe)
TTR [azurophil granule lumen] (Sus scrofa)
anon-AE003828.1 [azurophil granule lumen] (Drosophila melanogaster)
Cross References
RefSeq
NP_000362.1
ZINC - World Drugs
TTHY_HUMAN
OpenTargets
ENSG00000118271
ZINC - FDA approved
TTHY_HUMAN
ZINC - Substances
TTHY_HUMAN
ZINC target
P02766
ZINC - Biogenic
TTHY_HUMAN
PRO
P02766
PDB
1DVS
,
1E3F
,
3P3R
,
5TTR
,
2ROY
,
2B15
,
5CM1
,
4FI7
,
3I9A
,
4TLT
,
1TTR
,
3GRG
,
1F64
,
3CFM
,
4WO0
,
3DID
,
4MAS
,
2F8I
,
4PWK
,
4PME
,
1FHN
,
4DET
,
4YDN
,
4ABW
,
3IMR
,
4TQP
,
1BZ8
,
1BMZ
,
5E23
,
3IMV
,
2NOY
,
4N85
,
5N7C
,
3KGU
,
5AKV
,
5DWP
,
3BT0
,
5K1N
,
1TSH
,
4PWG
,
3DK0
,
5JID
,
6GR7
,
3U2I
,
5HJG
,
5DEJ
,
2B9A
,
6IMX
,
1QAB
,
1TZ8
,
1DVX
,
4WNS
,
1ETB
,
2TRH
,
3IMW
,
6E75
,
4IK7
,
3NEE
,
4PVL
,
5H0Z
,
4IKJ
,
3OZL
,
2G4G
,
5L4J
,
1THA
,
4IKI
,
2PAB
,
1F41
,
5U4D
,
2QGB
,
3TFB
,
4Y9G
,
2QEL
,
1ICT
,
3FCB
,
4PVN
,
3HJ0
,
5CLX
,
3TCT
,
4QXV
,
6FXU
,
5A6I
,
4PWF
,
4MRC
,
6D0W
,
6FZL
,
3M1O
,
5JIM
,
3P3U
,
6FWD
,
5AKS
,
2QGD
,
4FI6
,
5U4G
,
5L4F
,
3ESP
,
4TNF
,
1BZD
,
1TLM
,
3NEX
,
2FBR
,
4TM9
,
2H4E
,
6EP1
,
4TNG
,
4IK6
,
3IPE
,
6R67
,
5EN3
,
4Y9F
,
1Z7J
,
4TQ8
,
4HJU
,
4DES
,
1DVQ
,
5LLV
,
5NFE
,
4PM1
,
4IKL
,
4TLS
,
4ABV
,
6E70
,
3DJZ
,
3GRB
,
3KGT
,
4ANK
,
1TTA
,
1DVY
,
6GRP
,
4TLU
,
6E73
,
4MRB
,
6E76
,
1E4H
,
6FFT
,
3FC8
,
1QWH
,
5LLL
,
3DJT
,
2G4E
,
1TT6
,
4TNE
,
1ZCR
,
3DO4
,
2G9K
,
6R66
,
4Y9E
,
4ACT
,
6KGB
,
6E6Z
,
5CLY
,
3GLZ
,
3A4E
,
5E4A
,
3KGS
,
3OZK
,
1X7T
,
3CN2
,
5OQ0
,
5CNH
,
2NBO
,
5NFW
,
2QGC
,
5EZP
,
3IMU
,
1ZD6
,
1SOQ
,
4ABU
,
3D7P
,
5U49
,
4ABQ
,
1RLB
,
4PWE
,
5H0W
,
1U21
,
3CN4
,
2M5N
,
2G5U
,
3P3T
,
5K1J
,
5FW7
,
5H0X
,
5CR1
,
3NG5
,
5AL0
,
3NES
,
6E77
,
3CFQ
,
1SOK
,
5U4B
,
3IPB
,
5AYT
,
4DER
,
4HJT
,
5BOJ
,
3DGD
,
6TXW
,
1DVZ
,
4QRF
,
1TTB
,
1F86
,
1E5A
,
3SSG
,
4DEW
,
3I9P
,
6E74
,
4TQH
,
2G3Z
,
3DJS
,
5U4E
,
6IMY
,
3ESO
,
4QYA
,
4HJS
,
4IKK
,
5IHH
,
1BZE
,
3GS7
,
4N87
,
4TQI
,
4IIZ
,
4KY2
,
2QGE
,
4AC4
,
5FW6
,
4Y9C
,
5H0V
,
1GKO
,
3IMT
,
2FLM
,
5U48
,
6SDZ
,
2GAB
,
2F7I
,
4I85
,
4TLK
,
3A4D
,
5N5Q
,
3CN1
,
1DVT
,
6XTK
,
2B77
,
6TXV
,
5CN3
,
6R68
,
5L4M
,
6E71
,
3CFT
,
4TL5
,
4WNJ
,
3BSZ
,
2B14
,
4PMF
,
4I89
,
5TZL
,
3A4F
,
1X7S
,
3CN3
,
4DEU
,
5CLZ
,
1III
,
2WQA
,
3GS0
,
3I9I
,
4PWH
,
3CFN
,
5JIQ
,
5AKT
,
4YDM
,
1TTC
,
4PWI
,
3D2T
,
2ROX
,
4AC2
,
3B56
,
2G3X
,
1THC
,
3IMS
,
3ESN
,
4FI8
,
3P3S
,
3DJR
,
4PWJ
,
1Y1D
,
5AL8
,
3GS4
,
4L1T
,
4D7B
,
1FH2
,
5U4F
,
2NBP
,
6R6I
,
4Y9B
,
3DK2
,
4PVM
,
4HIQ
,
3CN0
,
5E4O
,
1G1O
,
4I87
,
1BM7
,
1IIK
,
5FO2
,
3W3B
,
1TYR
,
4N86
,
5N62
,
6E78
,
1DVU
,
3CXF
,
2B16
,
5H0Y
,
5L4I
,
1IJN
,
5U4A
,
1ETA
,
6E72
,
4HIS
,
4TKW
,
3U2J
,
5FW8
,
3NEO
,
5U4C
,
3CBR
,
3GPS
,
2TRY
,
4L1S
,
4TL4
ZINC - Metabolites
TTHY_HUMAN
GeneCards
P02766
HPA
ENSG00000118271-TTR
Ensembl
ENST00000237014
,
ENSP00000497927
,
ENSG00000118271
,
ENSP00000237014
,
ENST00000649620
ZINC - Predictions - Purchasable
TTHY_HUMAN
Orphanet
15674
HMDB Protein
HMDBP01831
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18848 ATF4
1
ATF4 [nucleoplasm]
(R-HSA-381016)
0.668
3
UniProt:P02753 RBP4
3
RBP4 I41N [extracellular region]
(R-HSA-2471954)
RBP4 G75D [extracellular region]
(R-HSA-2471928)
RBP4(19-201) [extracellular region]
(R-HSA-2453675)
0.667
4
UniProt:P25713 MT3
1
MT3 [cytosol]
(R-HSA-5660396)
0.593
3
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.558
2
UniProt:Q8N3R9 MPP5
1
MPP5 [plasma membrane]
(R-HSA-419969)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1-RAF1 fusion [cytosol]
(R-HSA-6802312)
p-ESRP1-RAF1 fusion [cytosol]
(R-HSA-6802523)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:Q8N163 CCAR2
2
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
DBC1 [nucleoplasm]
(R-HSA-3371479)
0.556
3
UniProt:Q13569 TDG
3
TDG [nucleoplasm]
(R-HSA-65812)
SUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
SUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
0.556
3
UniProt:Q06136 KDSR
1
KDSR [endoplasmic reticulum membrane]
(R-HSA-428134)
0.556
3
UniProt:Q9Y2D1 ATF5
1
ATF5 [nucleoplasm]
(R-HSA-9653719)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.556
3
UniProt:Q12873 CHD3
2
SUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
CHD3 [nucleoplasm]
(R-HSA-4657012)
0.553
2
UniProt:P08670 VIM
11
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.553
2
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.553
2
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