Reactome | TTR [azurophil granule lumen]

TTR [azurophil granule lumen]

Stable Identifier

R-HSA-6799366

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Transthyretin, TTHY_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02766 TTR

Gene Names

TTR, PALB

Chain

signal peptide:1-20, chain:21-147

Reference Genes

BioGPS Gene:7276 TTR

COSMIC (genes):TTR TTR

CTD Gene:7276 TTR

dbSNP Gene:7276 TTR

ENSEMBL:ENSG00000118271 TTR

HGNC:12405 TTR

KEGG Gene (Homo sapiens):7276 TTR

Monarch:7276 TTR

NCBI Gene:7276 TTR

OMIM:176300 TTR

UCSC:P02766 TTR

Reference Transcript

RefSeq:NM_000371.3 TTR

Other Identifiers

11754285_a_at

16851786

209660_at

32252_at

3783578

3783579

3783581

3783587

3783588

3783589

7276

8020795

A_23_P130333

GE80911

GO:0001523

GO:0002376

GO:0003674

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0006144

GO:0006629

GO:0006810

GO:0007165

GO:0008150

GO:0016192

GO:0030198

GO:0031410

GO:0032991

GO:0034641

GO:0035578

GO:0042562

GO:0042572

GO:0042802

GO:0043226

GO:0043312

GO:0044267

GO:0044281

GO:0044877

GO:0070062

GO:0070324

GO:0070327

M15517_cds5_at

PH_hs_0019852

PH_hs_0033292

TC18000129.hg

g5533090_3p_at

Participant Of

hasMember

Azurophil granule lumen proteins [azurophil granule lumen]

Other forms of this molecule

TTR [extracellular region]

Inferred To

ttr [azurophil granule lumen] (Danio rerio)

ttr [azurophil granule lumen] (Xenopus tropicalis)

Homologues of TTR [azurophil granule lumen] (Caenorhabditis elegans)

Ttr [azurophil granule lumen] (Mus musculus)

Ttr [azurophil granule lumen] (Rattus norvegicus)

TTR [azurophil granule lumen] (Caenorhabditis elegans)

TTR [azurophil granule lumen] (Canis familiaris)

TTR [azurophil granule lumen] (Dictyostelium discoideum)

TTR [azurophil granule lumen] (Gallus gallus)

TTR [azurophil granule lumen] (Schizosaccharomyces pombe)

TTR [azurophil granule lumen] (Sus scrofa)

anon-AE003828.1 [azurophil granule lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_000362.1

ZINC - World Drugs

TTHY_HUMAN

OpenTargets

ENSG00000118271

ZINC - FDA approved

TTHY_HUMAN

ZINC - Substances

TTHY_HUMAN

ZINC target

P02766

ZINC - Biogenic

TTHY_HUMAN

PRO

P02766

PDB

1DVS, 1E3F, 3P3R, 5TTR, 2ROY, 2B15, 5CM1, 4FI7, 3I9A, 4TLT, 1TTR, 3GRG, 1F64, 3CFM, 4WO0, 3DID, 4MAS, 2F8I, 4PWK, 4PME, 1FHN, 4DET, 4YDN, 4ABW, 3IMR, 4TQP, 1BZ8, 1BMZ, 5E23, 3IMV, 2NOY, 4N85, 5N7C, 3KGU, 5AKV, 5DWP, 3BT0, 5K1N, 1TSH, 4PWG, 3DK0, 5JID, 6GR7, 3U2I, 5HJG, 5DEJ, 2B9A, 6IMX, 1QAB, 1TZ8, 1DVX, 4WNS, 1ETB, 2TRH, 3IMW, 6E75, 4IK7, 3NEE, 4PVL, 5H0Z, 4IKJ, 3OZL, 2G4G, 5L4J, 1THA, 4IKI, 2PAB, 1F41, 5U4D, 2QGB, 3TFB, 4Y9G, 2QEL, 1ICT, 3FCB, 4PVN, 3HJ0, 5CLX, 3TCT, 4QXV, 6FXU, 5A6I, 4PWF, 4MRC, 6D0W, 6FZL, 3M1O, 5JIM, 3P3U, 6FWD, 5AKS, 2QGD, 4FI6, 5U4G, 5L4F, 3ESP, 4TNF, 1BZD, 1TLM, 3NEX, 2FBR, 4TM9, 2H4E, 6EP1, 4TNG, 4IK6, 3IPE, 6R67, 5EN3, 4Y9F, 1Z7J, 4TQ8, 4HJU, 4DES, 1DVQ, 5LLV, 5NFE, 4PM1, 4IKL, 4TLS, 4ABV, 6E70, 3DJZ, 3GRB, 3KGT, 4ANK, 1TTA, 1DVY, 6GRP, 4TLU, 6E73, 4MRB, 6E76, 1E4H, 6FFT, 3FC8, 1QWH, 5LLL, 3DJT, 2G4E, 1TT6, 4TNE, 1ZCR, 3DO4, 2G9K, 6R66, 4Y9E, 4ACT, 6KGB, 6E6Z, 5CLY, 3GLZ, 3A4E, 5E4A, 3KGS, 3OZK, 1X7T, 3CN2, 5OQ0, 5CNH, 2NBO, 5NFW, 2QGC, 5EZP, 3IMU, 1ZD6, 1SOQ, 4ABU, 3D7P, 5U49, 4ABQ, 1RLB, 4PWE, 5H0W, 1U21, 3CN4, 2M5N, 2G5U, 3P3T, 5K1J, 5FW7, 5H0X, 5CR1, 3NG5, 5AL0, 3NES, 6E77, 3CFQ, 1SOK, 5U4B, 3IPB, 5AYT, 4DER, 4HJT, 5BOJ, 3DGD, 6TXW, 1DVZ, 4QRF, 1TTB, 1F86, 1E5A, 3SSG, 4DEW, 3I9P, 6E74, 4TQH, 2G3Z, 3DJS, 5U4E, 6IMY, 3ESO, 4QYA, 4HJS, 4IKK, 5IHH, 1BZE, 3GS7, 4N87, 4TQI, 4IIZ, 4KY2, 2QGE, 4AC4, 5FW6, 4Y9C, 5H0V, 1GKO, 3IMT, 2FLM, 5U48, 6SDZ, 2GAB, 2F7I, 4I85, 4TLK, 3A4D, 5N5Q, 3CN1, 1DVT, 6XTK, 2B77, 6TXV, 5CN3, 6R68, 5L4M, 6E71, 3CFT, 4TL5, 4WNJ, 3BSZ, 2B14, 4PMF, 4I89, 5TZL, 3A4F, 1X7S, 3CN3, 4DEU, 5CLZ, 1III, 2WQA, 3GS0, 3I9I, 4PWH, 3CFN, 5JIQ, 5AKT, 4YDM, 1TTC, 4PWI, 3D2T, 2ROX, 4AC2, 3B56, 2G3X, 1THC, 3IMS, 3ESN, 4FI8, 3P3S, 3DJR, 4PWJ, 1Y1D, 5AL8, 3GS4, 4L1T, 4D7B, 1FH2, 5U4F, 2NBP, 6R6I, 4Y9B, 3DK2, 4PVM, 4HIQ, 3CN0, 5E4O, 1G1O, 4I87, 1BM7, 1IIK, 5FO2, 3W3B, 1TYR, 4N86, 5N62, 6E78, 1DVU, 3CXF, 2B16, 5H0Y, 5L4I, 1IJN, 5U4A, 1ETA, 6E72, 4HIS, 4TKW, 3U2J, 5FW8, 3NEO, 5U4C, 3CBR, 3GPS, 2TRY, 4L1S, 4TL4

ZINC - Metabolites

TTHY_HUMAN

GeneCards

P02766

HPA

ENSG00000118271-TTR

Ensembl

ENST00000237014, ENSP00000497927, ENSG00000118271, ENSP00000237014, ENST00000649620

ZINC - Predictions - Purchasable

TTHY_HUMAN

Orphanet

15674

HMDB Protein

HMDBP01831

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18848 ATF4	1	ATF4 [nucleoplasm] (R-HSA-381016)	0.668	3
UniProt:P02753 RBP4	3	RBP4 I41N [extracellular region] (R-HSA-2471954) RBP4 G75D [extracellular region] (R-HSA-2471928) RBP4(19-201) [extracellular region] (R-HSA-2453675)	0.667	4
UniProt:P25713 MT3	1	MT3 [cytosol] (R-HSA-5660396)	0.593	3
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.558	2
UniProt:Q8N3R9 MPP5	1	MPP5 [plasma membrane] (R-HSA-419969)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1-RAF1 fusion [cytosol] (R-HSA-6802312) p-ESRP1-RAF1 fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q8N163 CCAR2	2	p-T454-DBC1 [nucleoplasm] (R-HSA-3371569) DBC1 [nucleoplasm] (R-HSA-3371479)	0.556	3
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) SUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) SUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718)	0.556	3
UniProt:Q06136 KDSR	1	KDSR [endoplasmic reticulum membrane] (R-HSA-428134)	0.556	3
UniProt:Q9Y2D1 ATF5	1	ATF5 [nucleoplasm] (R-HSA-9653719)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.556	3
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.553	2
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2

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