HIPK2 phosphorylates TP53

Stable Identifier
Reaction [transition]
Homo sapiens
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HIPK2, activated by autophosphorylation in response to DNA damage, phosphorylates TP53 (p53) at serine residue S46 (D'Orazi et al. 2002, Hofmann et al. 2002). A TP53 transcriptional target TP53INP1 facilitates TP53 phosphorylation at S46 in response to double strand breaks and, together with HIPK2, promotes the transcription of TP53 apoptotic gene targets (Okamura et al. 2001, Tomasini et al. 2003).
Literature References
PubMed ID Title Journal Year
12851404 TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity

Malissen, B, Tomasini, R, Carrier, A, Dusetti, NJ, Isnardon, D, Samir, AA, Cecchinelli, B, Soddu, S, Iovanna, JL, Dagorn, JC

J. Biol. Chem. 2003
11780126 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

Higashimoto, Y, Piaggio, G, Cecchinelli, B, Soddu, S, Marchetti, A, Saito, S, Gostissa, M, Manni, I, Del Sal, G, D'Orazi, G, Fanciulli, M, Appella, E, Bruno, T, Coen, S

Nat. Cell Biol. 2002
11511362 p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

Arakawa, H, Nakanishi, H, Nakamura, Y, Monden, M, Taya, Y, Ng, CC, Tanaka, T, Okamura, S

Mol. Cell 2001
11740489 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Taya, Y, Möller, A, Sirma, H, Hofmann, TG, Schmitz, ML, Zentgraf, H, Will, H, Dröge, W

Nat. Cell Biol. 2002
Catalyst Activity

protein serine/threonine kinase activity of TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]

Orthologous Events
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