HIPK2 phosphorylates TP53

Stable Identifier
R-HSA-6799409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HIPK2, activated by autophosphorylation in response to DNA damage, phosphorylates TP53 (p53) at serine residue S46 (D'Orazi et al. 2002, Hofmann et al. 2002). A TP53 transcriptional target TP53INP1 facilitates TP53 phosphorylation at S46 in response to double strand breaks and, together with HIPK2, promotes the transcription of TP53 apoptotic gene targets (Okamura et al. 2001, Tomasini et al. 2003).

Literature References
PubMed ID Title Journal Year
11780126 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

D'Orazi, G, Cecchinelli, B, Bruno, T, Manni, I, Higashimoto, Y, Saito, S, Gostissa, M, Coen, S, Marchetti, A, Del Sal, G, Piaggio, G, Fanciulli, M, Appella, E, Soddu, S

Nat. Cell Biol. 2002
12851404 TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity

Tomasini, R, Samir, AA, Carrier, A, Isnardon, D, Cecchinelli, B, Soddu, S, Malissen, B, Dagorn, JC, Iovanna, JL, Dusetti, NJ

J. Biol. Chem. 2003
11511362 p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

Okamura, S, Arakawa, H, Tanaka, T, Nakanishi, H, Ng, CC, Taya, Y, Monden, M, Nakamura, Y

Mol. Cell 2001
11740489 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

Hofmann, TG, Möller, A, Sirma, H, Zentgraf, H, Taya, Y, Dröge, W, Will, H, Schmitz, ML

Nat. Cell Biol. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created