TP53 stimulates expression of the TP53I3 (PIG3) gene

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R-HSA-6799441
Type
Reaction [omitted]
Species
Homo sapiens
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TP53 (p53) activates transcription of the TP53I3 (PIG3) gene by binding to the pentanucleotide microsatellite sequence in the TP53I3 gene promoter that shares a limited similarity with the consensus p53 response element (Contente et al. 2002). Transcription of the TP53I3 gene can also be activated by p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004). ASPP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members, leading to increased binding of p53 family members to the TP53I3 promoter and enhanced transcription of TP53I3 (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).

Literature References
PubMed ID Title Journal Year
14729977 ASPP1 and ASPP2: common activators of p53 family members

Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X

Mol. Cell. Biol. 2004
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X

Mol. Cell 2001
11919562 A polymorphic microsatellite that mediates induction of PIG3 by p53

Contente, A, Dittmer, A, Koch, MC, Roth, J, Dobbelstein, M

Nat. Genet. 2002
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