Reactome | MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

Stable Identifier

R-HSA-6799581

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

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MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

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Endoplasmic reticulum-associated degradation of misfolded glycoproteins ensures only functional, correctly folded proteins exit from the endoplasmic reticulum and that misfolded ones are targeted for lysosomal degradation. Once located to the lysosome, epididymis-specific alpha-mannosidase (MAN2B2) can hydrolyse nondegraded oligosaccharides such as GlcNAc (Man)3 to GlcNAc (Man)2 quickly and GlcNAc (Man)2 to GlcNAc:Man slowly (Park et al. 2005, Venkatesan et al. 2009). MAN2B2 is ubiquitously expressed and belongs to a broad alpha-mannosidase family called class 2 alpha-mannosidases (CAZy glycosylhydrolase family 38, GH38). GH38 members are found in the Golgi complex, lysosomes, and cytosol where they are involved in either glycoprotein biosynthesis or catabolism.

Literature References

PubMed ID	Title	Journal	Year
16115860	Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism Meng, L, Yi, X, Moremen, KW, Mast, SW, Collins, RE, Strachan, H, Stanton, LH, Park, C	J. Biol. Chem.	2005
19722277	Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties Rose, DR, Venkatesan, M, Kuntz, DA	Protein Sci.	2009