Reactome: A Curated Pathway Database

GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P

Stable Identifier
R-HSA-6799604
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glucosamine-6-phosphate isomerases 1 and 2 (GNPDA1, 2) catalyse the reversible deamination and with an aldo/keto isomerisation of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate (Fru(6)P) and ammonia (NH3). GNDPA1 and 2 function as homohexamers in the cytosol. This reaction could provide a source of energy from catabolic pathways of hexosamines found in glycoproteins and glycolipids (Wolosker et al. 1998, Zhang et al. 2003, Arreola et al. 2003).

Literature References
Participants
Participant Of
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This entity is regulated by:
Title Physical Entity Activity
glucosamine-6-phosphate deaminase activity of GNPDA1,2 hexamers [cytosol] GNPDA1,2 hexamers [cytosol] glucosamine-6-phosphate deaminase activity (0004342)
Orthologous Events