GPX5,6 reduce H2O2 to H2O

Stable Identifier
R-HSA-6799695
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Epididymal secretory glutathione peroxidase (GPX5), a secreted and selenium-independent isoform of glutathione peroxidases, is present in very low levels in human sperm ejaculate. GPX5 has the potential to reduce hydrogen peroxide (H2O2) using glutathione (GSH), based on activity observed in rat and pig forms of the enzyme but its role in human epidydimis is unknown (Hall et al. 1998). Glutathione peroxidase 6 (GPX6) is thought to have peroxidase activity based on sequence similarity to GPX5.

Literature References
PubMed ID Title Journal Year
9639555 The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract

Hall, L, Williams, K, Perry, AC, Frayne, J, Jury, JA

Biochem. J. 1998
Participants
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Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX5, (GPX6) [extracellular region]
Physical Entity
Activity
Orthologous Events
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