Reactome | VCL [specific granule lumen]

VCL [specific granule lumen]

Stable Identifier

R-HSA-6799711

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule lumen

Synonyms

Vinculin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P18206 VCL

Gene Names

VCL

Chain

chain:1-1134

Reference Genes

BioGPS Gene:7414 VCL

COSMIC (genes):VCL VCL

CTD Gene:7414 VCL

dbSNP Gene:7414 VCL

ENSEMBL:ENSG00000035403 VCL

ENSEMBL_homo_sapiens_GENE:ENSG00000035403.18 VCL

HGNC:12665 VCL

KEGG Gene (Homo sapiens):7414 VCL

Monarch:7414 VCL

NCBI Gene:7414 VCL

OMIM:193065 VCL

UCSC:P18206 VCL

Reference Transcript

Other Identifiers

11744006_a_at

11750111_a_at

11757769_s_at

16706200

200930_PM_s_at

200930_s_at

200931_PM_s_at

200931_s_at

3252074

3252075

3252086

3252094

3252095

3252096

3252097

3252098

3252107

3252108

3252109

3252110

3252112

3252113

3252114

3252115

3252116

3252117

3252119

3252121

3252122

3252123

3252128

3252129

3252134

3252135

3252137

3252138

3252139

3252140

3252141

3252158

3252160

3252162

3252164

3252165

36601_at

7414

7928444

A_23_P202280

A_24_P47182

GE58543

GO:0002009

GO:0002102

GO:0002162

GO:0003779

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005903

GO:0005911

GO:0005912

GO:0005915

GO:0005916

GO:0005925

GO:0007155

GO:0007160

GO:0008013

GO:0008092

GO:0015629

GO:0016020

GO:0030032

GO:0030055

GO:0030154

GO:0030334

GO:0030336

GO:0031410

GO:0031625

GO:0032991

GO:0034330

GO:0034333

GO:0034394

GO:0034774

GO:0035580

GO:0035633

GO:0042060

GO:0042383

GO:0042995

GO:0043034

GO:0043226

GO:0043297

GO:0044291

GO:0045121

GO:0045294

GO:0045296

GO:0048675

GO:0048856

GO:0048870

GO:0051015

GO:0051893

GO:0060090

GO:0061826

GO:0070062

GO:0070161

GO:0070527

GO:0090136

GO:0090636

GO:0090637

GO:1903140

GO:1903561

GO:1904702

GO:1904813

GO:1990357

HMNXSV003052622

Hs.75350.0.A1_3p_a_at

ILMN_1661674

ILMN_1795429

ILMN_2413527

M33308_at

PH_hs_0004317

PH_hs_0031318

TC10000476.hg

g7669549_3p_a_at

p2006

Participates

as a member of

Specific granule lumen proteins [specific granule lumen] (Homo sapiens)

Other forms of this molecule

VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]

VCL(1-811)-ALK(1058-1620) fusion [cytosol]

VCL(95 kDa) [cytosol]

VCL [secretory granule lumen]

VCL [extracellular region]

VCL [ficolin-1-rich granule lumen]

VCL [cytosol]

Inferred To

VCL [specific granule lumen] (Bos taurus)

VCL [specific granule lumen] (Canis familiaris)

VCL [specific granule lumen] (Gallus gallus)

VCL [specific granule lumen] (Sus scrofa)

vcla [specific granule lumen] (Danio rerio)

Vcl [specific granule lumen] (Mus musculus)

Vcl [specific granule lumen] (Rattus norvegicus)

Vinc [specific granule lumen] (Drosophila melanogaster)

deb-1 [specific granule lumen] (Caenorhabditis elegans)

fip-2 [specific granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_003364.1, NP_054706.1

OpenTargets

ENSG00000035403

GeneCards

P18206

HPA

ENSG00000035403-VCL

Ensembl

ENST00000211998, ENSG00000035403, ENST00000372755, ENSP00000211998, ENSP00000361841

PRO

P18206

Pharos - Targets

P18206

Orphanet

17263

PDB

3TJ6, 7KTT, 4LN2, 3TJ5, 5L0D, 1TR2, 5L0J, 1RKC, 4EHP, 3VF0, 5O2Q, 5L0F, 3JBK, 2GWW, 5L0H, 4PR9, 1SYQ, 3RF3, 3H2U, 3S90, 7KTW, 6UPW, 5L0G, 1RKE, 2IBF, 7KTU, 6FUY, 3H2V, 3MYI, 5L0I, 5L0C, 4LNP, 2HSQ, 4DJ9, 1YDI, 7KTV

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18010 IPAA			0.758	7
UniProt:Q6XVZ2 Q6XVZ2			0.719	4
UniProt:B0BXR4 B0BXR4			0.65	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	9
UniProt:Q62417-2 SORBS1			0.591	3
UniProt:Q969V4 TEKT1			0.556	3
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.553	3
UniProt:Q15654 TRIP6			0.553	2
UniProt:P35221 CTNNA1	2	CTNNA1 [cytosol] (R-HSA-191697) CTNNA1 [plasma membrane] (R-HSA-191735)	0.527	2
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) N6-glycyl-L-lysine-RPS27A(1-76) [cytosol] (R-HSA-8869045) adenylatedlG76-RPS27A(1-76) [nucleoplasm] (R-HSA-8852078) RPS27A [cytosol] (R-HSA-8853524) adenylatedlG76-RPS27A(1-76) [cytosol] (R-HSA-8852065) Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane] (R-HSA-8943102) Ub-48-RPS27A(1-76) [lysosomal membrane] (R-HSA-9763033) Ub-48-RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-9763012) RPS27A(1-76) [endosome membrane] (R-HSA-939238) RPS27A(1-76) [plasma membrane] (R-HSA-3149457) Ub-29-RPS27A(1-76) [cytosol] (R-HSA-5689223) Ub-6-RPS27A(1-76) [cytosol] (R-HSA-5689098)	0.527	2
UniProt:Q7Z4L5 TTC21B	2	TTC21B [ciliary tip] (R-HSA-5625349) TTC21B [cilium] (R-HSA-5610430)	0.508	2

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