Reactome | PPP1R13B [nucleoplasm]

PPP1R13B [nucleoplasm]

Stable Identifier

R-HSA-6799775

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Apoptosis-stimulating of p53 protein 1, ASPP1, Protein phosphatase 1 regulatory subunit 13B

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Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of PUMA and translocation to mitochondria (Homo sapiens)
        
        TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        PPP1R13B [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        PPP1R13B [nucleoplasm] (Homo sapiens)
        
        TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        PPP1R13B [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)
        
        (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] (Homo sapiens)
        
        PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)
        
        PPP1R13B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96KQ4 PPP1R13B

Gene Names

PPP1R13B, ASPP1, KIAA0771

Chain

chain:1-1090

Reference Genes

BioGPS Gene:23368 PPP1R13B

COSMIC (genes):PPP1R13B PPP1R13B

CTD Gene:23368 PPP1R13B

dbSNP Gene:23368 PPP1R13B

ENSEMBL:ENSG00000088808 PPP1R13B

ENSEMBL_homo_sapiens_GENE:ENSG00000088808.18 PPP1R13B

HGNC:14950 PPP1R13B

KEGG Gene (Homo sapiens):23368 PPP1R13B

Monarch:23368 PPP1R13B

NCBI Gene:23368 PPP1R13B

OMIM:606455 PPP1R13B

UCSC:Q96KQ4 PPP1R13B

Reference Transcript

RefSeq:NM_015316.2 PPP1R13B

Other Identifiers

11742847_a_at

16797051

216347_PM_s_at

216347_s_at

23368

3580877

3580878

3580879

3580880

3580881

3580882

3580887

3580890

3580891

3580893

3580894

3580895

3580896

3580898

3580899

3580900

3580904

3580909

3580910

3580911

3580913

3580915

3580916

3580927

3580928

3580931

3580940

3580941

36538_at

7981460

A_23_P205273

A_33_P3365134

A_33_P3372501

GE53478

GO:0002039

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006915

GO:0008134

GO:0012501

GO:0023052

GO:0042981

GO:0043226

GO:0045786

GO:0048471

GO:0072332

HMNXSV003030255

Hs.6162.1.S1_3p_a_at

ILMN_1748831

PH_hs_0024186

TC14001544.hg

Participates

as a member of

PPP1R13B,TP53BP2 [nucleoplasm] (Homo sapiens)

Inferred To

ppp1r13b [nucleoplasm] (Xenopus tropicalis)

PPP1R13B [nucleoplasm] (Bos taurus)

PPP1R13B [nucleoplasm] (Canis familiaris)

PPP1R13B [nucleoplasm] (Gallus gallus)

PPP1R13B [nucleoplasm] (Sus scrofa)

ASPP [nucleoplasm] (Drosophila melanogaster)

Ppp1r13b [nucleoplasm] (Mus musculus)

Ppp1r13b [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_056131.2

OpenTargets

ENSG00000088808

HPA

ENSG00000088808-PPP1R13B

GeneCards

Q96KQ4

Ensembl

ENSG00000088808, ENST00000202556, ENSP00000202556

PRO

Q96KQ4

Pharos - Targets

Q96KQ4

PDB

6HL5

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.931	11
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.709	6
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1 [cytosol] (R-HSA-2995384) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q4G176 ACSF3	1	ACSF3 [mitochondrial matrix] (R-HSA-5696011)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q8IYH5 ZZZ3	1	ZZZ3 [nucleoplasm] (R-HSA-3662283)	0.556	3
UniProt:Q9NSC2 SALL1	1	SALL1 [nucleoplasm] (R-HSA-452500)	0.556	3
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.499	2

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