TP53 family members bind PPP1R13B or TP53BP2

Stable Identifier
R-HSA-6799777
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
p53 family members bind ASPP1 or ASPP2
Locations in the PathwayBrowser
Summation

TP53 (p53) forms a complex with PPP1R13B (ASPP1) or TP53BP2 (ASPP2). This interaction involves the DNA binding domain of TP53 and the C-terminus of ASSP proteins (Samuels-Lev et al. 2001, Patel et al. 2008). ASPP proteins can also form a complex with p53 family members TP63 (p63) and TP73 (p73) (Robinson et al. 2008, Patel et al. 2008). ASPP proteins enhance the binding of p53 family members to promoters of pro-apoptotic genes and promote their transcription, but do not affect the transcription of cell cycle regulators. ASPP proteins are frequently down-regulated in breast cancers that express wild-type TP53 (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).

Literature References
PubMed ID Title Journal Year
18676979 Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

Patel, S, George, R, Autore, F, Fraternali, F, Ladbury, JE, Nikolova, PV

Nucleic Acids Res. 2008
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X

Mol. Cell 2001
14729977 ASPP1 and ASPP2: common activators of p53 family members

Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X

Mol. Cell. Biol. 2004
18275817 Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73

Robinson, RA, Lu, X, Jones, EY, Siebold, C

Structure 2008
Participants
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