Reactome: A Curated Pathway Database

TP53 family members bind PPP1R13B or TP53BP2

Stable Identifier
R-HSA-6799777
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
p53 family members bind ASPP1 or ASPP2
Locations in the PathwayBrowser
Summation

TP53 (p53) forms a complex with PPP1R13B (ASPP1) or TP53BP2 (ASPP2). This interaction involves the DNA binding domain of TP53 and the C-terminus of ASSP proteins (Samuels-Lev et al. 2001, Patel et al. 2008). ASPP proteins can also form a complex with p53 family members TP63 (p63) and TP73 (p73) (Robinson et al. 2008, Patel et al. 2008). ASPP proteins enhance the binding of p53 family members to promoters of pro-apoptotic genes and promote their transcription, but do not affect the transcription of cell cycle regulators. ASPP proteins are frequently down-regulated in breast cancers that express wild-type TP53 (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).

Literature References
Participants
Participant Of
Orthologous Events