Reactome | TP53 family members bind PPP1R13B or TP53BP2

TP53 family members bind PPP1R13B or TP53BP2

Stable Identifier

R-HSA-6799777

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p53 family members bind ASPP1 or ASPP2

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)

Summation

TP53 (p53) forms a complex with PPP1R13B (ASPP1) or TP53BP2 (ASPP2). This interaction involves the DNA binding domain of TP53 and the C-terminus of ASSP proteins (Samuels-Lev et al. 2001, Patel et al. 2008). ASPP proteins can also form a complex with p53 family members TP63 (p63) and TP73 (p73) (Robinson et al. 2008, Patel et al. 2008). ASPP proteins enhance the binding of p53 family members to promoters of pro-apoptotic genes and promote their transcription, but do not affect the transcription of cell cycle regulators. ASPP proteins are frequently down-regulated in breast cancers that express wild-type TP53 (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
18676979	Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax Patel, S, George, R, Autore, F, Fraternali, F, Ladbury, JE, Nikolova, PV	Nucleic Acids Res.	2008
11684014	ASPP proteins specifically stimulate the apoptotic function of p53 Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X	Mol. Cell	2001
14729977	ASPP1 and ASPP2: common activators of p53 family members Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X	Mol. Cell. Biol.	2004
18275817	Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73 Robinson, RA, Lu, X, Jones, EY, Siebold, C	Structure	2008