Metal sequestration by antimicrobial proteins

Stable Identifier
R-HSA-6799990
Type
Pathway
Species
Homo sapiens
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Summation

Metals are necessary for all forms of life including microorganisms, evidenced by the fact that metal cations are constituents of approximately 40% of all proteins crystallized to date (Waldron KJ et al. 2009; Foster AW et al. 2014; Guengerich FP 2014, 2015). The ability of microorganisms to maintain the intracellular metal quota is essential and allows microorganisms to adapt to a variety of environments. Accordingly, the ability of the host to control metal quota at inflammation sites can influence host-pathogen interactions. The host may restrict microbial growth either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms (Becker KW & Skaar EP 2014).

Literature References
PubMed ID Title Journal Year
25211180 Metal limitation and toxicity at the interface between host and pathogen

Becker, KW, Skaar, EP

FEMS Microbiol. Rev. 2014
26055725 Introduction: Metals in Biology: METALS AT THE HOST-PATHOGEN INTERFACE

Guengerich, FP

J. Biol. Chem. 2015
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