Reactome | TMEM219 [plasma membrane]

TMEM219 [plasma membrane]

Stable Identifier

R-HSA-6800018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Insulin-like growth factor-binding protein 3 receptor, IGFBP-3R, Transmembrane protein 219

Locations in the PathwayBrowser for interactor UniProt:Q9Y287 ITM2B

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Death Receptors and Ligands (Homo sapiens)
        
        IGFBP3 binds TMEM219 (Homo sapiens)
        
        TMEM219 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86XT9 TMEM219

Gene Names

TMEM219

Chain

signal peptide:1-38, chain:39-240

Reference Genes

BioGPS Gene:124446 TMEM219

COSMIC (genes):TMEM219 TMEM219

CTD Gene:124446 TMEM219

dbSNP Gene:124446 TMEM219

ENSEMBL:ENSG00000149932 TMEM219

ENSEMBL_homo_sapiens_GENE:ENSG00000149932.17 TMEM219

HGNC:25201 TMEM219

KEGG Gene (Homo sapiens):124446 TMEM219

Monarch:124446 TMEM219

NCBI Gene:124446 TMEM219

OMIM:620290 TMEM219

UCSC:Q86XT9 TMEM219

Reference Transcript

Other Identifiers

11746481_a_at

124446

16817736

224981_PM_at

224981_at

3655807

3655809

3655810

3655811

3655812

3655813

3655814

3655815

3655817

3655818

3655819

3655820

3655822

78792_at

7994683

A_14_P103755

A_23_P77562

GE79241

GE87996

GO:0005515

GO:0005886

GO:0006915

GO:0012501

GO:0016020

HMNXSV003004110

HMNXSV003052245

Hs.291623.0.A1_3p_at

ILMN_1737644

PH_hs_0040135

TC16000334.hg

Participates

as a component of

IGFBP3:TMEM219 [plasma membrane] (Homo sapiens)

as an input of

IGFBP3 binds TMEM219 (Homo sapiens)

Inferred To

TMEM219 [plasma membrane] (Bos taurus)

TMEM219 [plasma membrane] (Sus scrofa)

si:ch211-43o9.5 [plasma membrane] (Danio rerio)

Tmem219 [plasma membrane] (Mus musculus)

Tmem219 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_005255180.1, NP_919256.1, NP_001077082.1

OpenTargets

ENSG00000149932

GeneCards

Q86XT9

HPA

ENSG00000149932-TMEM219

Ensembl

ENSP00000459813, ENSP00000388485, ENST00000279396, ENSP00000456960, ENSP00000279396, ENST00000570255, ENSG00000149932, ENST00000561899, ENSP00000457492, ENST00000566848, ENST00000414689

PRO

Q86XT9

Pharos - Targets

Q86XT9

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.709	9
UniProt:P17936 IGFBP3	15	IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499)	0.66	8
UniProt:Q8TDD5 MCOLN3	1	MCOLN3 [plasma membrane] (R-HSA-3211773)	0.527	2
UniProt:Q9NPD7 NRN1	2	cleaved GPI-NRN1 [extracellular region] (R-HSA-8941063) GPI-NRN1 [plasma membrane] (R-HSA-8940728)	0.527	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.527	2

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