Reactome | N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII

N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII

Stable Identifier

R-HSA-6800149

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII

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Inorganic arsenic (iAs) compounds are human carcinogens. The most toxic arsenic metabolite is monomethylarsonous acid (MMAIII). Arsenic (3+) methyltransferase (AS3MT) is the primary enzyme responsible for methylating MMAIII to the less toxic dimethylarsonic acid (DMAA). A human ortholog of yeast MTQ2, HemK methyltransferase family member 2 (aka N(6)-adenine-specific DNA methyltransferase 1, N6AMT1), is also able to methylate MMAIII using S-adenosyl L-methionine as methyl donor (Ren et al. 2011). N6AMT1 forms a heterodimer with multifunctional methyltransferase subunit TRM112-like protein (TRMT112) (Figaro et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18539146	HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1 Scrima, N, Heurgué-Hamard, V, Figaro, S, Buckingham, RH	FEBS Lett.	2008
21193388	Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity Jo, WJ, Zhang, L, Dills, R, Kalman, DA, Aleshin, M, Ren, X, Vulpe, CD, Smith, MT	Environ. Health Perspect.	2011