Reactome | LAMTOR2 [tertiary granule membrane]

LAMTOR2 [tertiary granule membrane]

Stable Identifier

R-HSA-6800165

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Synonyms

Ragulator complex protein LAMTOR2, LTOR2_HUMAN

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External Reference Information

External Reference

UniProt:Q9Y2Q5 LAMTOR2

Gene Names

LAMTOR2, MAPBPIP, ROBLD3, HSPC003

Chain

chain:1-125

Reference Genes

BioGPS Gene:28956 LAMTOR2

COSMIC (genes):LAMTOR2 LAMTOR2

CTD Gene:28956 LAMTOR2

dbSNP Gene:28956 LAMTOR2

ENSEMBL:ENSG00000116586 LAMTOR2

ENSEMBL_homo_sapiens_GENE:ENSG00000116586.12 LAMTOR2

HGNC:29796 LAMTOR2

KEGG Gene (Homo sapiens):28956 LAMTOR2

Monarch:28956 LAMTOR2

NCBI Gene:28956 LAMTOR2

OMIM:610389 LAMTOR2

UCSC:Q9Y2Q5 LAMTOR2

Reference Transcript

Other Identifiers

11717016_a_at

11757690_a_at

16671889

218291_PM_at

218291_at

2361243

2361244

2361245

2361247

2361248

2361251

2361253

2361254

2361255

2361256

28956

45731_at

7906072

A_23_P103698

A_24_P182433

A_33_P3246068

GE58544

GO:0001558

GO:0005085

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0008104

GO:0010008

GO:0010761

GO:0016020

GO:0023052

GO:0031410

GO:0031902

GO:0032008

GO:0034330

GO:0035579

GO:0038202

GO:0043226

GO:0043410

GO:0048870

GO:0060090

GO:0070821

GO:0071230

GO:0071986

GO:0098772

GO:0150116

GO:1902414

GO:1904263

GO:1990877

HMNXSV003010810

ILMN_1756352

PH_hs_0017001

PH_hs_0032796

TC01001310.hg

g7661727_3p_s_at

Participates

as a member of

Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)

Other forms of this molecule

LAMTOR2 [specific granule membrane]

LAMTOR2 [plasma membrane]

LAMTOR2 [endosome membrane]

LAMTOR2 [lysosomal membrane]

Inferred To

mapbpip [tertiary granule membrane] (Dictyostelium discoideum)

lamtor2 [tertiary granule membrane] (Danio rerio)

lamtor2 [tertiary granule membrane] (Xenopus tropicalis)

LAMTOR2 [tertiary granule membrane] (Bos taurus)

LAMTOR2 [tertiary granule membrane] (Canis familiaris)

LAMTOR2 [tertiary granule membrane] (Gallus gallus)

LAMTOR2 [tertiary granule membrane] (Schizosaccharomyces pombe)

LAMTOR2 [tertiary granule membrane] (Sus scrofa)

ENSRNOG00000066475 [tertiary granule membrane] (Rattus norvegicus)

Lamtor2 [tertiary granule membrane] (Drosophila melanogaster)

Lamtor2 [tertiary granule membrane] (Mus musculus)

lmtr-2 [tertiary granule membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_054736.1, NP_001138736.1

OpenTargets

ENSG00000116586

GeneCards

Q9Y2Q5

HPA

ENSG00000116586-LAMTOR2

Ensembl

ENSP00000357288, ENSP00000357287, ENST00000368302, ENSG00000116586, ENST00000368305, ENST00000368304, ENSP00000357285

PRO

Q9Y2Q5

Pharos - Targets

Q9Y2Q5

Orphanet

17582

PDB

5Y3A, 7UX2, 5YK3, 6B9X, 7UXH, 6NZD, 6WJ2, 7T3B, 6EHR, 7T3A, 5X6V, 5X6U, 6WJ3, 6EHP, 5Y39, 6ULG, 8DHB, 7UXC, 7T3C, 6U62

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHA4 LAMTOR3	5	LAMTOR3 [specific granule membrane] (R-HSA-6800178) LAMTOR3 [plasma membrane] (R-HSA-6806307) LAMTOR3 [tertiary granule membrane] (R-HSA-6800189) LAMTOR3 [endosome membrane] (R-HSA-5693294) LAMTOR3 [lysosomal membrane] (R-HSA-5653581)	0.961	40
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.937	25
UniProt:Q9HB90 RRAGC	1	RRAGC [cytosol] (R-HSA-5653949)	0.812	13
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.812	10
UniProt:Q7L523 RRAGA	2	K63polyUb-K142,K220,K230,K244-RRAGA [cytosol] (R-HSA-8938830) RRAGA [cytosol] (R-HSA-5653577)	0.788	9
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.758	9
UniProt:Q96GS4 BORC6			0.742	7
UniProt:Q5VZM2 RRAGB	1	RRAGB [cytosol] (R-HSA-5653579)	0.725	8
UniProt:Q8NBW4 SLC38A9	1	SLC38A9 [lysosomal membrane] (R-HSA-5215938)	0.669	5
UniProt:Q5VZM2-2 RRAGB			0.558	3
UniProt:P11279 LAMP1	3	LAMP1 [ficolin-1-rich granule membrane] (R-HSA-6800966) LAMP1 [plasma membrane] (R-HSA-6806268) LAMP1 [azurophil granule membrane] (R-HSA-6799162)	0.527	3
UniProt:Q9NQL2 RRAGD	1	RRAGD [cytosol] (R-HSA-5653953)	0.527	5
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2

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